Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Solubility of Flurbiprofen in CO2 and CO2 + Methanol

Chin, G. J.[Gui Jin], Chee, Z. H.[Zi Hui], Chen, W.[Wenda], Rajendran, A.[Arvind]
J. Chem. Eng. Data 2010, 55, 4, 1542-1546
ABSTRACT
The solubility of (R,S)-2-(2-fluorobiphenyl-4-yl)propanoic acid (flurbiprofen) in supercritical carbon dioxide and in a mixed solvent consisting of carbon dioxide and methanol at (303.15 and 313.15) K between the pressures of (10.0 and 20.0) MPa is reported. The solubilities were measured using a direct visualization technique. The experimental data is described using the Peng-Robinson equation of state (PR EoS) together with a one-parameter van der Waals mixing rule.
Compounds
# Formula Name
1 C15H13FO2 2-(2-fluoro-4-biphenylyl)propanoic acid
2 CH4O methanol
3 CO2 carbon dioxide
Datasets
The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type Compound-# Property Variable Constraint Phase Method #Points
  • POMD
  • 3
  • 1
  • Mole fraction - 1 ; Fluid (supercritical or subcritical phases)
  • Temperature, K; Fluid (supercritical or subcritical phases)
  • Pressure, kPa; Fluid (supercritical or subcritical phases)
  • Fluid (supercritical or subcritical phases)
  • Crystal - 1
  • Direct visualization technique
  • 17
  • POMD
  • 2
  • 3
  • 1
  • Mole fraction - 1 ; Fluid (supercritical or subcritical phases)
  • Temperature, K; Fluid (supercritical or subcritical phases)
  • Pressure, kPa; Fluid (supercritical or subcritical phases)
  • Mole fraction - 2; Fluid (supercritical or subcritical phases)
  • Fluid (supercritical or subcritical phases)
  • Crystal - 3
  • Direct visualization technique
  • 30