ABSTRACT

Electrical conductivity and mutual diffusion coefficients of aqueous solutions of two ephedrine enantiomers ((1S,2R)-(+)-ephedrine hydrochloride and (1R,2S)-(-)-ephedrine hydrochloride), at a concentration range of (0 to 0.17) mol*dm-3 and (0.001 to 0.01) mol*dm-3, respectively) have been measured. The effect of temperature, ranging from (298.15 to 323.15) K, has also been studied. The experimental data of electrical conductivity follow the Kohlrausch equation, and the hydration radius of ephedrines can be calculated from Walden rule equation. ?he activation enthalpies of the transport process for ephedrine cations, (1R,2S)-(-)-ephedrine and (1S,2R)-(+)-ephedrine, 7.4 (+- 0.5) kJ*mol-1 and 19.3 (+- 0.4) kJ*mol-1, respectively, show a slight discrimination between both enantiomers. The experimental data are discussed on the basis of the Onsager-Fuoss model. The Nernst diffusion coefficients for (1R,2S)-(-)- and (1S,2R)-(+)-ephedrine hydrochloride in water, at (298.15 and 310.15) K, derived from conductance and from diffusion experiments are in good agreement.

Compounds

#	Formula	Name
1	C10H16ClNO	ephedrine hydrochloride
2	C10H16ClNO	D-.alpha.-(1-methylaminoethyl)benzyl alcohol
3	H2O	water

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	1 3	Molar conductivity, S*m2/mol ; Liquid	Temperature, K; Liquid Amount concentration (molarity), mol/dm3 - 1; Liquid	Pressure, kPa; Liquid	Liquid	Shedlovsky-type conductance cell	180
POMD	1 3	Binary diffusion coefficient, m2/s ; Liquid	Temperature, K; Liquid Amount concentration (molarity), mol/dm3 - 1; Liquid	Pressure, kPa; Liquid	Liquid	Open capillary	10
POMD	3 2	Molar conductivity, S*m2/mol ; Liquid	Temperature, K; Liquid Amount concentration (molarity), mol/dm3 - 2; Liquid	Pressure, kPa; Liquid	Liquid	Shedlovsky-type conductance cell	180
POMD	3 2	Binary diffusion coefficient, m2/s ; Liquid	Temperature, K; Liquid Amount concentration (molarity), mol/dm3 - 2; Liquid	Pressure, kPa; Liquid	Liquid	Open capillary	10

Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Transport Properties of Aqueous Solutions of (1R,2S)-(-)- and (1S,2R)-(+)-Ephedrine Hydrochloride at Different Temperatures

Valente, A. J. M.[Artur J. M.], Ribeiro, A. C. F.[Ana C. F.], Marques, J. M. C.[Jorge M. C.], Abreu, P. E.[Paulo E.], Lobo, V. M. M.[Victor M. M.], Kataky, R.[Ritu]

ABSTRACT