Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Solubility of 1,3-Dimethyl-7H-purine-2,6-dione (Theophylline) in Supercritical Carbon Dioxide

de la Fuente, J. C.[Juan C.], Nunez, G.[Gonzalo], del Valle, J. M.[Jose M.]
J. Chem. Eng. Data 2009, 54, 11, 3034-3036
ABSTRACT
This contribution provides complementary experimental data of solubility (y2, molar fraction) of solid 1,3-dimethyl-7H-purine-2,6-dione (theophylline) in supercritical CO2 as a function of temperature (313 K ? T ? 333 K) and pressure (10 MPa ? P ? 44 MPa). A static-analytic methodology was used with standard deviations from average solubility measurements of ? 38 % and with estimated inherit errors ? 25 %. The solubility of theophylline increased with the CO2 density from 0.33*10-5 mol*mol-1 at 797.2 kg*m-3 (313 K, 16 MPa) to 3.3*10-5 mol*mol-1 at 890.2 kg*m-3 (333 K, 40 MPa). The solubility increased with pressure and temperature. Experimental solubilities were correlated with a density-based model with three adjustable parameters, which was valid for solvent densities in the range of (400 to 950) kg*m-3.
Compounds
# Formula Name
1 C7H8N4O2 3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione
2 CO2 carbon dioxide
Datasets
The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type Compound-# Property Variable Constraint Phase Method #Points
  • POMD
  • 1
  • 2
  • Mole fraction - 1 ; Fluid (supercritical or subcritical phases)
  • Temperature, K; Fluid (supercritical or subcritical phases)
  • Pressure, kPa; Fluid (supercritical or subcritical phases)
  • Fluid (supercritical or subcritical phases)
  • Crystal - 1
  • Chromatography
  • 27