ABSTRACT

New experimental solubility data of Naproxen in supercritical CO2 for (313 to 353) K and pressures ranging from (15 to 40) MPa are presented. This covers the range where processes with supercritical fluids such as Rapid Expansion from Supercritical Fluids are typically performed. In addition, the solid-liquid-gas equilibrium line for the CO2 + Naproxen system was determined from (0.1 to 30) MPa. The solubility data are correlated by three different methods: two methods for the density-solubility correlation and one method for the pressure-solubility correlation. Different literature data and predictions of the sublimation pressure of Naproxen, which are required for the solubility correlation, are compared.

Compounds

#	Formula	Name
1	C14H14O3	(S)-(+)-naproxen
2	CO2	carbon dioxide

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Phase	Method	#Points
POMD	1	Molar enthalpy of transition or fusion, kJ/mol ; Crystal		Crystal Liquid Air at 1 atmosphere	DSC	1
POMD	1	Normal melting temperature, K ; Crystal		Crystal Liquid Air at 1 atmosphere	DTA	1
POMD	2 1	Vapor or sublimation pressure, kPa ; Liquid	Temperature, K; Liquid	Liquid Gas Crystal - 1	CCELL:UFactor:16	12
POMD	2 1	Mole fraction - 1 ; Fluid (supercritical or subcritical phases)	Temperature, K; Fluid (supercritical or subcritical phases) Pressure, kPa; Fluid (supercritical or subcritical phases)	Fluid (supercritical or subcritical phases) Crystal - 1	gravimetric analysis	28

Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Experimental and Theoretical Investigation of the Phase Behavior of Naproxen in Supercritical CO2

Turk, M.[Michael], Kraska, T.[Thomas]

ABSTRACT