ABSTRACT

Notriptyline hydrochloride and trimipramine maleate are used as antidepressants and analgesics. The density and viscosity of the aqueous solutions of these compounds are measured in a range of molality, m ) (9.7 E 10-6 to 32.5 E 10-6) mol E g-1, at T ) (293.15 to 313.15) K using a commercial densimeter and viscometer. The apparent molar volume (V O), partial molar volume (Vm 0 ), partial molar expansivity (E2 0 ), thermal expansion coefficient (R2), and Hepler fs constant ( Y2Vm 0 / YT2) are calculated from the density data. The values of the B-coefficient and hydration number (Hn) are computed from the viscosity data.

Compounds

#	Formula	Name
1	C19H22ClN	3-(10,110dihydro-5H-dibenzo[1,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine hydrochloride
2	C24H30N2O4	trimipramine maleate
3	H2O	water

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	1 3	Viscosity, Pa*s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid	Pressure, kPa; Liquid	Liquid	Rotational	42
POMD	1 3	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	42
POMD	2 3	Viscosity, Pa*s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 2; Liquid	Pressure, kPa; Liquid	Liquid	Rotational	42
POMD	2 3	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 2; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	42

Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Volumetric and Viscometric Studies of Antidepressant Drugs in Aqueous Medium at Different Temperatures

Iqbal, M. J.[Muhammad Javed], Chaudhry, M. A.[Mansoora Ahmed]

ABSTRACT