Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Solubility and Metastable Zone of Cefoperazone Sodium in Acetone + Water System

Chen, Q.[Qiaoli], Wang, Y.[Yongli], Li, Y.[Yanbin], Wang, J.-K.[Jing-Kang]
J. Chem. Eng. Data 2009, 54, 3, 1123-1125
ABSTRACT
The solubility and the metastable zone of cefoperazone sodium in acetone + water were determined by the gravimetrical method and the laser monitoring observation technique, respectively. The experimental data can be well correlated by (CNIBS)/Redlich-Kister equation. All results were important for the crystallization process s control of cefoperazone sodium.
Compounds
# Formula Name
1 C25H26N9NaO8S2 sodium (6S,7S)-7-{[(2S)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-2-(4-hydroxyphenyl)acetyl]amino}-3-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
2 H2O water
3 C3H6O acetone
Datasets
The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type Compound-# Property Variable Constraint Phase Method #Points
  • POMD
  • 1
  • Normal melting temperature, K ; Crystal
  • Crystal
  • Liquid
  • Air at 1 atmosphere
  • DTA
  • 1
  • POMD
  • 3
  • 2
  • 1
  • Mole fraction - 1 ; Liquid
  • Temperature, K; Liquid
  • Solvent: Mole fraction - 2; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 1
  • Gravimetrical method
  • 17