ABSTRACT

Experimental solubilities of three antiepileptic drugs, that is, lamotrigine, diazepam, and clonazepam in ethanol + water mixtures at 298.15 K were reported. The solubility of drugs was increased with the addition of ethanol, reached the maximum values, and then decreased with further increase in ethanol concentrations. The Jouyban-Acree model was fitted to the data, and the solubilities were reproduced using two previously developed relationships employing a number of the solvent s and solute s parameters and the solubility data in monosolvents in which the overall mean deviations (OMDs) of the models were 6.2 %, 22.3 %, and 23.2 %.

Compounds

#	Formula	Name
1	C9H7Cl2N5	lamotrigine
2	C16H13ClN2O	7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one
3	C15H10ClN3O3	clonazepam
4	C2H6O	ethanol
5	H2O	water

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	5 1	Amount concentration (molarity), mol/dm3 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid		Liquid Crystal - 1	SPECTR	1
POMD	5 1	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid		Liquid Crystal - 1	PYCNOM::UFactor:16	1
POMD	4 1	Amount concentration (molarity), mol/dm3 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid		Liquid Crystal - 1	SPECTR	1
POMD	4 1	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid		Liquid Crystal - 1	PYCNOM::UFactor:16	1
POMD	2 5	Amount concentration (molarity), mol/dm3 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid		Liquid Crystal - 2	SPECTR	1
POMD	2 5	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid		Liquid Crystal - 2	PYCNOM::UFactor:16	1
POMD	4 2	Amount concentration (molarity), mol/dm3 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid		Liquid Crystal - 2	SPECTR	1
POMD	4 2	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid		Liquid Crystal - 2	PYCNOM::UFactor:16	1
POMD	3 5	Amount concentration (molarity), mol/dm3 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid		Liquid Crystal - 3	SPECTR	1
POMD	3 5	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid		Liquid Crystal - 3	PYCNOM::UFactor:24	1
POMD	4 3	Amount concentration (molarity), mol/dm3 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid		Liquid Crystal - 3	SPECTR	1
POMD	4 3	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid		Liquid Crystal - 3	PYCNOM:UFactor:24	1
POMD	4 5 1	Amount concentration (molarity), mol/dm3 - 1 ; Liquid	Solvent: Volume fraction - 4; Liquid	Pressure, kPa; Liquid Temperature, K; Liquid	Liquid Crystal - 1	SPECTR	11
POMD	4 5 1	Mass density, kg/m3 ; Liquid	Solvent: Volume fraction - 4; Liquid	Pressure, kPa; Liquid Temperature, K; Liquid	Liquid Crystal - 1	PYCNOM:UFactor:16	11
POMD	4 2 5	Amount concentration (molarity), mol/dm3 - 2 ; Liquid	Solvent: Volume fraction - 4; Liquid	Pressure, kPa; Liquid Temperature, K; Liquid	Liquid Crystal - 2	SPECTR	11
POMD	4 2 5	Mass density, kg/m3 ; Liquid	Solvent: Volume fraction - 4; Liquid	Pressure, kPa; Liquid Temperature, K; Liquid	Liquid Crystal - 2	PYCNOM:UFactor:16	11
POMD	4 3 5	Amount concentration (molarity), mol/dm3 - 3 ; Liquid	Solvent: Volume fraction - 4; Liquid	Pressure, kPa; Liquid Temperature, K; Liquid	Liquid Crystal - 3	SPECTR	11
POMD	4 3 5	Mass density, kg/m3 ; Liquid	Solvent: Volume fraction - 4; Liquid	Pressure, kPa; Liquid Temperature, K; Liquid	Liquid Crystal - 3	PYCNOM:UFactor:24	11

Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Solubility of Lamotrigine, Diazepam, and Clonazepam in Ethanol + Water Mixtures at 298.15 K

Shayanfar, A.[Ali], Fakhree, M. A. A.[Mohammad A. A.], Acree, Jr., W. E.[William E.], Jouyban, A.[Abolghasem]

ABSTRACT