ABSTRACT

The solubility of valsartan in pure methyl acetate, n-butyl acetate, acetonitrile, N,N-dimethylformamide, dichloromethane, chloroform, and ethanol + water binary mixtures was measured by a synthetic method over the temperature range (278.15 to 313.15) K at atmospheric pressure. The results show that the solubility of valsartan increases with increasing temperature in all six pure solvents and ethanol + water binary mixtures, and it increases with increasing mole fraction of ethanol in the binary mixtures. The experimental data were correlated using the modified Apelblat model, and the agreement with the experimental data was very good.

Compounds

#	Formula	Name
1	C24H29N5O3	valsartan
2	C3H6O2	methyl ethanoate
3	C3H7NO	dimethylformamide
4	CH2Cl2	dichloromethane
5	C6H12O2	butyl ethanoate
6	C2H3N	acetonitrile
7	CHCl3	trichloromethane
8	C2H6O	ethanol
9	H2O	water

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	2 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	laser monitoring	8
POMD	3 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	laser monitoring	8
POMD	4 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	laser monitoring	8
POMD	5 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	laser monitoring	8
POMD	6 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	laser monitoring	8
POMD	7 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	laser monitoring	8
POMD	8 9 1	Mole fraction - 1 ; Liquid	Solvent: Mole fraction - 8; Liquid Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	laser monitoring	48

Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Solubility of Valsartan in Different Organic Solvents and Ethanol + Water Binary Mixtures from (278.15 to 313.15) K

Liu, Y., Wang, J.[Jingkang], Wang, X.[Xiaobo], Liu, P.[Peng], Pang, F.[Fei]

ABSTRACT