The solubilities of chloroquine diphosphate and 4,7-dichloroquinoline in water, ethanol, tetrahydrofuran, acetone, and acetonitrile were measured over the temperature range of (298.2 to 333.2) K. The solubilities of both analytes in different solvents increase smoothly with temperature. On the basis of the solubility data, it can be observed that the highest solubilities for chloroquine diphosphate and 4,7-dichloroquinoline were obtained in pure water and tetrahydrofuran, respectively. The temperature dependence of the solubility data was correlated by the modified Apelblat model. The calculated solubilities show good agreement with the experimental solubility data in the temperature range studied.
Compounds
#
Formula
Name
1
C18H32ClN3O8P2
chloroquine diphosphate
2
C9H5Cl2N
4,7-dichloroquinoline
3
C2H6O
ethanol
4
C4H8O
tetrahydrofuran
5
C2H3N
acetonitrile
6
C3H6O
acetone
7
H2O
water
Datasets
The table above is generated from the ThermoML associated json file (link above).
POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied;
the numbers refer to the table of compounds on the left.