Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Solubility of Losartan Potassium in Different Binary Solvents from (293.15 to 343.15) K

Guo, K.[Kun], Yin, Q.[Qiuxiang], Zhang, M.[Meijing], Wang, J.[Jingkang]
J. Chem. Eng. Data 2008, 53, 5, 1138-1140
ABSTRACT
The solubility of losartan potassium in mixed 2-propanol + water and 2-propanol + cyclohexane solvents was measured at the temperature ranging from (293.15 to 343.15) K under atmospheric pressure. The experimental data were correlated by the CNIBS/Redlich Kister model. The results show that the solubility of losartan potassium increases with increasing temperature in these two binary mixed solvents and increases with the increasing mole fraction of water while decreasing mole fraction of cyclohexane, respectively.
Compounds
# Formula Name
1 C22H22ClKN6O Losartan potassium
2 C3H8O propan-2-ol
3 C6H12 cyclohexane
4 H2O water
Datasets
The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type Compound-# Property Variable Constraint Phase Method #Points
  • POMD
  • 2
  • 4
  • 1
  • Mole fraction - 1 ; Liquid
  • Temperature, K; Liquid
  • Solvent: Mole fraction - 4; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 1
  • Laser Monitoring
  • 48
  • POMD
  • 2
  • 3
  • 1
  • Mole fraction - 1 ; Liquid
  • Temperature, K; Liquid
  • Solvent: Mole fraction - 3; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 1
  • Laser Monitoring
  • 48