Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Solubilities of Adefovir Dipivoxil in Different Binary Solvents at 298.15 K

Hou, G.[Guangyang], Yin, Q.[Qiuxiang], Yang, Y.[Yu], Hu, Y.[Yang], Zhang, M.[Meijing], Wang, J.[Jingkang]
J. Chem. Eng. Data 2008, 53, 4, 1021-1023
ABSTRACT
The solubility data of adefovir dipivoxil in five different binary mixed solvents formed by isopropyl ether with ethanol, 2-propanol, dichloromethane, ethyl acetate, and acetone at 298.15 K were measured with the mole fraction of isopropyl ether ranging from 0.000 to 1.000. A laser monitoring observation technique was used to determine the dissolution of the solid phase in a solid + liquid mixture. The solubility data were correlated with a function of the binary solvent mole fractions by the combined nearly ideal binary solvent (NIBS)/Redlich Kister equation.
Compounds
# Formula Name
1 C20H32N5O8P 9-[2-bis(pivaloyloxymethyl)phosphonmethoxyethyl]adenine
2 C6H14O diisopropyl ether
3 C2H6O ethanol
4 C3H8O propan-2-ol
5 CH2Cl2 dichloromethane
6 C4H8O2 ethyl acetate
7 C3H6O acetone
Datasets
The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type Compound-# Property Variable Constraint Phase Method #Points
  • POMD
  • 3
  • 1
  • Mole fraction - 1 ; Liquid
  • Pressure, kPa; Liquid
  • Temperature, K; Liquid
  • Liquid
  • Crystal - 1
  • OTHER::sMethod:Beer's Law
  • 1
  • POMD
  • 2
  • 1
  • Mole fraction - 1 ; Liquid
  • Pressure, kPa; Liquid
  • Temperature, K; Liquid
  • Liquid
  • Crystal - 1
  • OTHER::sMethod:Beer's Law
  • 2
  • POMD
  • 4
  • 1
  • Mole fraction - 1 ; Liquid
  • Pressure, kPa; Liquid
  • Temperature, K; Liquid
  • Liquid
  • Crystal - 1
  • OTHER::sMethod:Beer's Law
  • 1
  • POMD
  • 5
  • 1
  • Mole fraction - 1 ; Liquid
  • Pressure, kPa; Liquid
  • Temperature, K; Liquid
  • Liquid
  • Crystal - 1
  • OTHER::sMethod:Beer's Law
  • 1
  • POMD
  • 6
  • 1
  • Mole fraction - 1 ; Liquid
  • Pressure, kPa; Liquid
  • Temperature, K; Liquid
  • Liquid
  • Crystal - 1
  • OTHER::sMethod:Beer's Law
  • 1
  • POMD
  • 7
  • 1
  • Mole fraction - 1 ; Liquid
  • Pressure, kPa; Liquid
  • Temperature, K; Liquid
  • Liquid
  • Crystal - 1
  • Beer's Law
  • 1
  • POMD
  • 4
  • 2
  • 1
  • Mole fraction - 1 ; Liquid
  • Solvent: Mole fraction - 2; Liquid
  • Temperature, K; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 1
  • Beer's Law
  • 11
  • POMD
  • 3
  • 2
  • 1
  • Mole fraction - 1 ; Liquid
  • Solvent: Mole fraction - 2; Liquid
  • Temperature, K; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 1
  • Beer's Law
  • 11
  • POMD
  • 5
  • 2
  • 1
  • Mole fraction - 1 ; Liquid
  • Solvent: Mole fraction - 2; Liquid
  • Temperature, K; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 1
  • Beer's Law
  • 11
  • POMD
  • 2
  • 6
  • 1
  • Mole fraction - 1 ; Liquid
  • Solvent: Mole fraction - 2; Liquid
  • Temperature, K; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 1
  • Beer's Law
  • 11
  • POMD
  • 7
  • 2
  • 1
  • Mole fraction - 1 ; Liquid
  • Solvent: Mole fraction - 2; Liquid
  • Temperature, K; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 1
  • Beer's Law
  • 11