Name: ThermoML Representation of Published Experimental Data from Journal of Chemical and Engineering Data (0021-9568, American Chemical Society)
Creator: Thermodynamics Research Center
License: https://www.nist.gov/open/license

ABSTRACT

The solubilities of trimethoprim (TMP) in methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, 2-butanol, acetone, and tetrahydrofuran were measured using a laser technique in the temperature range from (278 to 333) K. The results were correlated with a modified Apelblat equation, which can be used as a useful model in the refining process of TMP.

Compounds

#	Formula	Name
1	C14H18N4O3	5-[(3,4,5-trimethoxyphenyl)methyl]-2,4-pyrimidinediamine
2	CH4O	methanol
3	C2H6O	ethanol
4	C3H8O	propan-1-ol
5	C3H8O	propan-2-ol
6	C4H10O	butan-1-ol
7	C4H10O	butan-2-ol
8	C3H6O	acetone
9	C4H8O	tetrahydrofuran

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	2 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	adding known mass of solute until laser intensity is not maximum	12
POMD	3 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	adding known mass of solute until laser intensity is not maximum	13
POMD	4 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	adding known mass of solute until laser intensity is not maximum	12
POMD	5 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	adding known mass of solute until laser intensity is not maximum	12
POMD	6 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	adding known mass of solute until laser intensity is not maximum	12
POMD	7 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	adding known mass of solute until laser intensity is not maximum	12
POMD	8 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	adding known mass of solute until laser intensity is not maximum	10
POMD	9 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	adding known mass of solute until laser intensity is not maximum	12

Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Solubility of Trimethoprim (TMP) in Different Organic Solvents from (278 to 333) K

Li, Q.-S.[Qun-Sheng], Li, Z.[Zhao], Wang, S.[Shui]

ABSTRACT