ABSTRACT

Surface behavior and bulk properties of two phenothiazine drugs, fluphenazine and trifluoperazine dihydrochlorides, are reported. Surface activity studies for both amphiphilic drugs were carried out in aqueous solutions at 20 deg C by surface tension measurements. The volumetric and compressibility properties of the drugs were derived from density and ultrasound velocity measurements. Critical concentrations were determined by surface tension and ultrasound data. The experiments were realized in aqueous and buffered (pH 3.0, 5.5, and 9.2) media at 20 deg C. The buffered media were chosen below and above the different pKa s that the drug molecules present (pKa1 and pKa2 of 3.90 and 8.10, respectively).

Compounds

#	Formula	Name
1	H2O	water
2	C22H28Cl2F3N3OS	fluphenazine dihydrochloride
3	C21H26Cl2F3N3S	trifluoperazine dihydrochloride

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	2 1	Surface tension liquid-gas, N/m ; Liquid	Molality, mol/kg - 2; Liquid	Temperature, K; Liquid	Liquid Air at 1 atmosphere	RINGTE:UFactor:2	14
POMD	2 1	Speed of sound, m/s ; Liquid	Molality, mol/kg - 2; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid	Sing-around technique in a fixed-path interferometer	15
POMD	2 1	Mass density, kg/m3 ; Liquid	Molality, mol/kg - 2; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid	Vibrating tube method	15
POMD	3 1	Surface tension liquid-gas, N/m ; Liquid	Molality, mol/kg - 3; Liquid	Temperature, K; Liquid	Liquid Air at 1 atmosphere	RINGTE:UFactor:2	14
POMD	3 1	Speed of sound, m/s ; Liquid	Molality, mol/kg - 3; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid	Sing-around technique in a fixed-path interferometer	19
POMD	3 1	Mass density, kg/m3 ; Liquid	Molality, mol/kg - 3; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid	Vibrating tube method	19

Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Surface and Bulk Properties of Two Amphiphilic Phenothiazine Drugs in Different Aqueous Media

Chemma, M. A.[Mohammad Arif], Siddiq, M.[Mohammad], Barbosa, S.[Silvia], Toboada, P.[Pablo], Mosquera, V.[Victor]

ABSTRACT