Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Thermodynamic Study of Warfarin Sodium Salt: Surface Tension, Conductivity, and Density Measurements

Cheema, M. A.[Mohammad Arif], Castro, E.[Emilio], Taboada, P.[Pablo], Siddiq, M.[Mohammad], Mosquera, V.[Victor]
J. Chem. Eng. Data 2007, 52, 6, 2315-2318
ABSTRACT
The thermodynamic properties in aqueous solution of the amphiphilic anticoagulant drug warfarin sodium in the temperature range (20 to 50) deg C were determined. The surface behavior and the critical micelle concentration (cmc) at 20 deg C were determined by surface tension measurements. The electrical conductivity was measured as a function of the concentration at various temperatures. The Phillips and Williams methods were applied to obtain the critical micelle concentration from these data. Both methods lead to similar values of the cmc. Measurements of density in the range of concentrations from (0.005 to 0.400) molakg-1 were carried out at (20, 30, 40, and 50) deg C. From these results, the apparent molal volumes have been calculated as a function of concentration and temperature.
Compounds
# Formula Name
1 H2O water
2 C19H15NaO4 warfarin sodium
Datasets
The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type Compound-# Property Variable Constraint Phase Method #Points
  • POMD
  • 2
  • 1
  • Surface tension liquid-gas, N/m ; Liquid
  • Molality, mol/kg - 2; Liquid
  • Temperature, K; Liquid
  • Liquid
  • Air at 1 atmosphere
  • RINGTE:UFactor:4
  • 20
  • POMD
  • 2
  • 1
  • Electrical conductivity, S/m ; Liquid
  • Temperature, K; Liquid
  • Molality, mol/kg - 2; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Alternating current cell with electrodes
  • 76
  • POMD
  • 2
  • 1
  • Mass density, kg/m3 ; Liquid
  • Temperature, K; Liquid
  • Molality, mol/kg - 2; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • VIBTUB:UFactor:16
  • 84