ABSTRACT

Apparent molal volumes of two local anesthetics, lidocaine HCl and procaine HCl, in water at (298.15, 303.15, and 310.15) K have been measured in the concentration range from (0.01 to 0.1) molakg-1. The densities were obtained with a magnetic float densimeter. The concentration dependence of V has been calculated using the Redlich and Meyer equation. The values of apparent molal volumes at infinite dilution, V 0, the empirical constants BV, and the partial molal expansibilities, E 0, were calculated. The results are interpreted in terms of competitive effects between electrostriction and hydrophobic solvation.

Compounds

#	Formula	Name
1	ClK	potassium chloride
2	H2O	water
3	C14H23ClN2O	lidocaine hydrochloride
4	C13H21ClN2O2	2-diethylaminoethyl p-aminobenzoate hydrochloride

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	1 2	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid	Pressure, kPa; Liquid	Liquid	Buoyancy - hydrostatic balance with magnetic suspension - one sinker	3
POMD	3 2	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 3; Liquid	Pressure, kPa; Liquid	Liquid	Buoyancy - hydrostatic balance with magnetic suspension - one sinker	31
POMD	4 2	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 4; Liquid	Pressure, kPa; Liquid	Liquid	Buoyancy - hydrostatic balance with magnetic suspension - one sinker	30

Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Apparent Molal Volumes of Lidocaine-HCl and Procaine-HCl in Aqueous Solution as a Function of Temperature

Torres, D. R.[Daniel R.], Blanco, L. H.[Luis H.], Martinez, F.[Fleming], Vargas, E. F.[Edgar F.]

ABSTRACT