Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Standard Molar Enthalpies of Formation and Thermal Stabilities of Artemisinin and Its Two Derivatives: Artemether and Artesunate

Dong, J.-X.[Jia-Xin], Qi, Z.-D.[Zu-De], Zhang, Z.-H.[Zhong-Hai], Liu, Y.[Yi]
J. Chem. Eng. Data 2007, 52, 3, 1045-1049
ABSTRACT
The constant-volume energy of combustion of crystalline artemisinin and its two derivatives, artemether and artesunate, in oxygen at T = 298.15 K was determined to be {-(7546.53 +- 3.24), -(7582.28 +- 3.09), and -(8150.75 +- 4.24)} kJ*mol-1 using combustion calorimetry, respectively. The derived standard molar enthalpies of formation of the three compounds in crystalline states at T = 298.15 K were {-(1492.81 +- 7.62), -(2419.75 +- 7.52), and -(3320.12 +- 9.90)} kJ*mol-1, respectively. The thermal stabilities of the three compounds were also investigated by thermal analysis combined with an FT-IR method.
Compounds
# Formula Name
1 CO2 carbon dioxide
2 H2O water
3 O2 oxygen
4 C15H22O5 artemisinin
5 C16H26O5 beta-artemether
6 C19H28O8 artesunate
Datasets
The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type Compound-# Property Variable Constraint Phase Method #Points
  • POMD
  • 4
  • Normal melting temperature, K ; Crystal
  • Crystal
  • Liquid
  • Air at 1 atmosphere
  • DTA
  • 1
  • POMD
  • 5
  • Normal melting temperature, K ; Crystal
  • Crystal
  • Liquid
  • Air at 1 atmosphere
  • DTA
  • 1
  • POMD
  • 6
  • Normal melting temperature, K ; Crystal
  • Crystal
  • Liquid
  • Air at 1 atmosphere
  • DTA
  • 1
  • RXND
  • 4
  • 1
  • 2
  • 3
  • Molar internal energy of reaction at constant volume, kJ/mol
  • Static bomb calorimetry
  • 1
  • RXND
  • 5
  • 1
  • 2
  • 3
  • Molar internal energy of reaction at constant volume, kJ/mol
  • Static bomb calorimetry
  • 1
  • RXND
  • 6
  • 1
  • 2
  • 3
  • Molar internal energy of reaction at constant volume, kJ/mol
  • Static bomb calorimetry
  • 1