The dissolution of sodium cefotaxime in 15 solvents were investigated. Only five solvents (formamide, N,N-dimethylformamide, dimethyl sulfoxide, water, and N-methylpyrrolidone) showed good solvency for the solid. The solubilities of sodium cefotaxime in N,N-dimethylformamide, formamide, and N-methylpyrrolidone were determined between the temperature range from (278.15 to 308.15) K, in water they were measured between (278.15 and 303.15) K, and in dimethyl sulfoxide they were determined between (293.15 and 308.15) K. A laser monitoring observation technique was used to determine the dissolution of the solid phase in a solid-liquid mixture. The solubilities of sodium cefotaxime in all solvents measured increase with temperature, and the solubilities of sodium cefotaxime also depend on the polarity of the solvent to some extent. The experimental solubility data were correlated with a semiempirical equation.
Compounds
#
Formula
Name
1
C16H16N5NaO7S2
cefotaxime sodium salt
2
CH3NO
formamide
3
C3H7NO
dimethylformamide
4
C2H6OS
dimethyl sulfoxide
5
H2O
water
6
C5H9NO
N-methylpyrrolidone
Datasets
The table above is generated from the ThermoML associated json file (link above).
POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied;
the numbers refer to the table of compounds on the left.