Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Solubility of Glycyrrhizin in supercritical carbon dioxide with and without cosolvent

Jia, J.-f.[Jing-fu], Zabihi, F.[Fatemeh], Gao, Y.-h.[Ya-hui], Zhao, Y.-p.[Ya-ping]
J. Chem. Eng. Data 2015, 60, 6, 1744-1749
ABSTRACT
The solubility of glycyrrhizin in supercritical carbon dioxide (SCCO2) with cosolvent ethanol at the mole fraction of (0, 0.02, and 0.04) was measured, respectively, at pressures of (9 to 21) MPa and temperatures of (308, 318, and 328) K. The results revealed that the glycyrrhizin solubility depended on the pressure, temperature, and cosolvent mole fraction. The glycyrrhizin solubility in pure SCCO2 was well correlated with Chrastil, Bartle, and Mendez-Santiago and Teja models with the average absolute relative deviation (AARD) below 6.82 %. The glycyrrhizin solubility in SCCO2 with cosolvent was correlated by Chrastil modified by Gonzalez (Chrastil-G), and MST modified by Sauseau (MST-S) models with satisfactory AARD below 3.85 %. The results provide fundamental data in designing extraction of glycyrrhizin from the licorice or preparation of its particle using SCCO2 techniques.
Compounds
# Formula Name
1 C42H62O16 Glycyrrhizin
2 CO2 carbon dioxide
3 C2H6O ethanol
4 C7H6O3 2-hydroxybenzoic acid
Datasets
The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type Compound-# Property Variable Constraint Phase Method #Points
  • POMD
  • 2
  • 1
  • Mole fraction - 1 ; Fluid (supercritical or subcritical phases)
  • Temperature, K; Fluid (supercritical or subcritical phases)
  • Pressure, kPa; Fluid (supercritical or subcritical phases)
  • Fluid (supercritical or subcritical phases)
  • Crystal - 1
  • UV-vis spectrophotometry
  • 15
  • POMD
  • 3
  • 2
  • 1
  • Mole fraction - 1 ; Fluid (supercritical or subcritical phases)
  • Temperature, K; Fluid (supercritical or subcritical phases)
  • Pressure, kPa; Fluid (supercritical or subcritical phases)
  • Solvent: Mole fraction - 3; Fluid (supercritical or subcritical phases)
  • Fluid (supercritical or subcritical phases)
  • Crystal - 1
  • UV-vis spectrophotometry
  • 30
  • POMD
  • 4
  • 2
  • Mole fraction - 4 ; Liquid
  • Pressure, kPa; Liquid
  • Temperature, K; Liquid
  • Liquid
  • Crystal - 4
  • UV-vis spectrophotometry
  • 6