Solubility and Solution Thermodynamics of Diphenoxylate in Different Pure Solvents
Qing, X. Y.[Xue Yan], Fu, H. L.[Hua Lin], Shu, G.[Gang], Liu, M. J.[Meng Jiao], Zhou, J. Y.[Jian Yu], Wu, W. B.[Wen Bin], Zhang, Y. L.[Yan Li], Zhou, J. J.[Jun Jie]
The solubility data of diphenoxylate in pure solvents of water, methanol, ethanol, acetone, acetonitrile, 2-propanol were measured within the temperature range of 293.15 318.15 K by a static analytical method under atmospheric pressure. Several commonly used thermodynamic models, including the ideal solution model, the modified Apelblat equation and the Buchowski-Ksiazaczak ?h equation, were applied to correlate the experimental solubility data. The experimental results show that the solubility increases with the increasing temperature, and the highest solubility is in methanol, the lowest in pure water. Results of these measurements were well-correlated with the three equations above, but the modified Apelblat equation is more suitable in regressing the solubility data of diphenoxylate. Through the Van t Hoff equation, the enthalpy and the entropy in different solvents can be calculated.
Compounds
#
Formula
Name
1
CH4O
methanol
2
C30H32N2O2
Diphenoxylate
3
C3H6O
acetone
4
C3H8O
propan-2-ol
5
C2H6O
ethanol
6
C2H3N
acetonitrile
7
H2O
water
Datasets
The table above is generated from the ThermoML associated json file (link above).
POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied;
the numbers refer to the table of compounds on the left.