ABSTRACT

The solubility of (2S)-pyrrolidine-2-carboxylic acid in pure alcohols (methanol, ethanol, isopropyl alcohol, and butan-1-ol) and the aqueous alcohols (methanol, ethanol, and isopropyl alcohol) mixtures was measured by a dynamic method via a laser monitoring technique. The solubility in the pure alcohols follows the order methanol greater than ethanol greater than butan-1-ol greater than isopropyl alcohol. In the binary mixtures, the solubility decreases with the increase of alcohol concentration. The experimental solubility was fitted by the modified Apelblat equation, combined nearly ideal binary solvent/Redlich Kister (CNIBS/R-K) model, and Van t Hoff equation. The dissolution is endothermic and the dissolution driving force converts from enthalpy-driven to entropy-driven.

Compounds

#	Formula	Name
1	C5H9NO2	L-proline
2	CH4O	methanol
3	C2H6O	ethanol
4	C4H10O	butan-1-ol
5	C3H8O	propan-2-ol
6	H2O	water

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	2 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	laser monitoring technique	5
POMD	3 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	laser monitoring technique	6
POMD	4 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	laser monitoring technique	6
POMD	5 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	laser monitoring technique	6
POMD	2 1 6	Mole fraction - 1 ; Liquid	Solvent: Mole fraction - 2; Liquid Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Laser Monitoring Technique	30
POMD	3 1 6	Mole fraction - 1 ; Liquid	Solvent: Mole fraction - 3; Liquid Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Laser Monitoring Technique	36
POMD	5 1 6	Mole fraction - 1 ; Liquid	Solvent: Mole fraction - 5; Liquid Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Laser Monitoring Technique	36
POMD	1 6	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Laser Monitoring Technique	11

Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Solubility and Thermodynamic Properties of (2S)-Pyrrolidine-2-carboxylic Acid in Water, Alcohols, and Water Alcohol Mixtures

Duan, E.[Erhong], Wang, K.[Kunkun], Li, X.[Xue], Chen, Z.[Zidan], Sun, H.[Hua]

ABSTRACT