The solubilities of biotin in water, methanol, ethanol, acetic acid, dimethylformamide (DMF), and dimethyl sulfoxide (DMSO) were measured at temperatures ranging from 298.15 K to 333.85 K (p = 0.1 MPa) by the synthetic method with a laser monitoring dynamic technique. The mole fraction solubilities of biotin were observed to be highest in DMSO, and be lowest in water. The experimental data were well-correlated with the modified Apelblat equation, van t Hoff equation, and ?h equation, in which the correlation coefficients (R2) were noted in the range of 0.997 to 1.000 and the root-mean-square deviations (rmsd) were less than 2.82 %. Thermodynamic studies showed that dissolution of biotin was an endothermic and spontaneous process in all selected solvents.
Compounds
#
Formula
Name
1
C10H16N2O3S
D(+)-Biotin
2
CH4O
methanol
3
C2H6O
ethanol
4
C2H4O2
acetic acid
5
C3H7NO
dimethylformamide
6
C2H6OS
dimethyl sulfoxide
7
H2O
water
Datasets
The table above is generated from the ThermoML associated json file (link above).
POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied;
the numbers refer to the table of compounds on the left.