The solubility of ibuprofen sodium dihydrate (ISD) in acetone + water mixtures was measured by the gravimetric method at temperatures ranging from (279.55 to 312.05) K. The measured solubilities were correlated by the modified Apelblat equation, the ?h (Buchowski) equation, the van t Hoff model, the combined nearly ideal binary solvent/Redlich Kister (CNIBS/R-K) equation, and the general single model. The modified Apelblat equation was the best model for correlating the solubility of ISD, while the general single model fits the best for mixed solvents. The standard enthalpy, entropy, and Gibbs energy of the dissociation process of ISD were calculated by the van t Hoff equation and the modified Apelblat model. In addition, there was a maximum value of solubility at a certain acetone mole fraction in the acetone + water mixture.
Compounds
#
Formula
Name
1
C13H17NaO2
sodium ibuprofen
2
C13H21NaO4
sodium 2-(4-isobutylphenyl)propanoate dihydrate
3
C3H6O
acetone
4
H2O
water
Datasets
The table above is generated from the ThermoML associated json file (link above).
POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied;
the numbers refer to the table of compounds on the left.