Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

ABSTRACT

The present work describes the synthesis, characterization, and solubility studies of some biologically active pyrimidine derivatives. The characterization of these synthesized compounds was done by mass, IR, and 1H NMR spectral techniques. Further, the solubility of these compounds has been studied in methanol, N,N-dimethylformamide (DMF), and carbon tetrachloride (CCl4) by gravimetrical method from (298.15 to 328.15) K under atmospheric pressure, and the solubility data were correlated against temperature. The solubility is found to increase with temperature and order of solubility is found to be DMF greater than methanol greater than CCl4. The modified Apelblat and Buchowski Ksiazczak ?h equations were used to correlate the experimental solubility data. Further, some thermodynamic parameters such as dissolution enthalpy (?Hsol), Gibb s free energy (?Gsol), and entropy (?Ssol) of mixing have also been calculated. The positive values of enthalpy and Gibbs energy of solution suggest that the dissolution process to be endothermic and is spontaneous.