Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Solubility of Dexamethasone in Supercritical Carbon Dioxide with and without a Cosolvent

Tang, C.[Chuan], Guan, Y.-X.[Yi-Xin], Yao, S.-J.[Shan-Jing], Zhu, Z.-Q.[Zi-Qiang]
J. Chem. Eng. Data 2014, 59, 11, 3359-3364
ABSTRACT
The solubility of dexamethasone, a synthetic glucocorticoid, in supercritical CO2 and together with 3.0 mol % ethanol as a cosolvent was measured at different temperatures (313.2, 318.2, and 323.2) K and pressures ranging from (10.0 to 25.0) MPa by a static analytical method. The obtained solubility of dexamethasone was between 1.19*10 6 and 1.52*10 6 in pure supercritical CO2 and between 1.97*10 6 and 2.98*10 6 in supercritical CO2 with a cosolvent. The experimental data in supercritical CO2 in the absence and presence of a cosolvent were correlated using four density-based semiempirical models, that is, Chrastil, Kumar and Johnston, Bartle, and Mendez-Santiago and Teja models. The results indicated that the Kumar and Johnston model gave a better correlated result than the other three with an average absolute relative deviation [AARD (%)] value lower than 2.15 %.
Compounds
# Formula Name
1 C22H29FO5 (11.beta.,16.alpha.)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1.4-diene-3,20-dione
2 C2H6O ethanol
3 CO2 carbon dioxide
Datasets
The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type Compound-# Property Variable Constraint Phase Method #Points
  • POMD
  • 1
  • 3
  • Mole fraction - 1 ; Fluid (supercritical or subcritical phases)
  • Temperature, K; Fluid (supercritical or subcritical phases)
  • Pressure, kPa; Fluid (supercritical or subcritical phases)
  • Fluid (supercritical or subcritical phases)
  • Crystal - 1
  • Static Analytical Method
  • 15
  • POMD
  • 1
  • 2
  • 3
  • Mole fraction - 1 ; Fluid (supercritical or subcritical phases)
  • Temperature, K; Fluid (supercritical or subcritical phases)
  • Pressure, kPa; Fluid (supercritical or subcritical phases)
  • Solvent: Mole fraction - 2; Fluid (supercritical or subcritical phases)
  • Fluid (supercritical or subcritical phases)
  • Crystal - 1
  • Static Analytical Method
  • 12