Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

ABSTRACT

The solid liquid equilibria of 4-amino-3,6-dichloropyridazine (ADCP) in seven pure organic solvents including methanol, acetone, ethanol, dichloromethane, ethyl acetate, 1,4-dioxane, and tetrahydrofuran were determined with the synthetic method from (278.15 to 333.15) K at atmospheric pressure using a laser monitoring observation technique. The measured solubility data increased with the rise of temperature. These solubility data were correlated with two models: the modified Apelblat and ?h (Buchowski) equation. The relative deviation of the modified Apelblat equation was no more than 2.1 %, while that of ?h equation was less than 4.5 %. Better correlation results were obtained in most solvents with modified Apelblat equation. Furthermore, using van t Hoff plot, the calculation was performed to obtain the apparent dissolution enthalpy and entropy of the solution of ADCP in these solvents, based on which the apparent dissolution Gibbs free energy change was deduced.