The solubility of enrofloxacin in ethanol, water, 2-propanol, acetonitrile, and acetic ether was measured by a static analytical method from (303.15 to 321.05) K. The concentrations of enrofloxacin in saturated solvent were analyzed by UV spectrometry. The experimental solubility data for pure solvents decreases in the order acetonitrile greater than acetic ether greater than2-propanol greater than ethanol greater than water. The experimental solubility data was correlated by the modified Apelblat equation, the ideal solution equation, and the Clarke Glew equation. The results show that the mole fraction solubility of enrofloxacin in pure solvents increased with increasing temperature; the Clarke Glew two parameters equation (Clarke Glew 2 equation) can provide a more accurate mathematical model than the modified Apelblat equation, the ideal solution equation, and the Clarke Glew three parameters equation (Clarke Glew 3 equation). In addition, the discussion of Gibbs energy, enthalpy, and entropy for enrofloxacin in different solvents indicated that the dissolution process of enrofloxacin was endothermic and entropy-driven.
Compounds
#
Formula
Name
1
C19H22FN3O3
Enrofloxacin
2
C2H6O
ethanol
3
H2O
water
4
C3H8O
propan-2-ol
5
C2H3N
acetonitrile
6
C4H8O2
ethyl acetate
Datasets
The table above is generated from the ThermoML associated json file (link above).
POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied;
the numbers refer to the table of compounds on the left.