ABSTRACT

Temperature-dependent solubility data of bioactive compound hesperidin has not been reported in any solvent in the literature so far. Therefore, the aim of the current study was to measure the solubility of bioactive compound hesperidin in six different pure solvents namely water, ethanol, isopropyl alcohol (IPA), propylene glycol (PG), poly(ethylene glycol)-400 (PEG-400), and 1-butanol from (298.15 to 333.15) K using the shake flask method. The experimental solubilities of hesperidin were regressed by Apelblat equation with root-mean-square deviations in the range of 6.32*10 7 to 0.184 in all solvents investigated. The correlation coefficients in pure solvents were observed in the range of 0.995 to 0.999. The mole fraction solubility of hesperidin was found to be higher in PEG-400 (6.33*10 3 at 298.15 K) and PG (5.35*10 4 at 298.15 K) as compared to water (1.47*10 7 at 298.15 K), ethanol (3.45*10 5 at 298.15 K), IPA (1.53*10 5 at 298.15 K), and 1-butanol (3.15*10 4 at 298.15 K). The data of the current study could be useful in crystallization/purification and formulation development of hesperidin in the chemical/pharmaceutical industry.

Compounds

#	Formula	Name
1	C28H34O15	(S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)chroman-4-one
2	C2H6O	ethanol
3	C3H8O2	1,2-propanediol
4	C3H8O	propan-2-ol
5	C4H10O	butan-1-ol
6	H2O	water

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	1 6	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Chromatography	5
POMD	2 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Chromatography	5
POMD	3 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Chromatography	5
POMD	5 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Chromatography	5
POMD	4 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Chromatography	5

Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Solubility of Bioactive Compound Hesperidin in Six Pure Solvents at (298.15 to 333.15) K

Anwer, M. K.[Md Khalid], Al-Shdefat, R.[Ramadan], Jamil, S.[Shahid], Alam, P.[Prawez], Abdel-Kader, M. S.[Maged S.], Shakeel, F.[Faiyaz]

ABSTRACT