The solubility of azithromycin monohydrate in ethanol, propan-2-ol, butan-1-ol, ethyl ethanoate, and 2-propanone from 278.15 K to 323.15 K was measured by a synthetic method. The measured solubility data were correlated by van t Hoff equation, modified Apelblat equation, ?h equation, Wilson, and NRTL models. It was found that the Wilson equations give the best correlation results. The mixing properties including the mixing free Gibbs energy, enthalpy, and entropy of azithromycin monohydrate were also calculated based on the Wilson model parameters. The results indicate that the dissolution process of azithromycin monohydrate in all tested solvents is spontaneous and endothermic.
Compounds
#
Formula
Name
1
C38H74N2O13
Azithromycin monohydrate
2
C2H6O
ethanol
3
C3H8O
propan-2-ol
4
C4H10O
butan-1-ol
5
C4H8O2
ethyl acetate
6
C3H6O
acetone
Datasets
The table above is generated from the ThermoML associated json file (link above).
POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied;
the numbers refer to the table of compounds on the left.
Type
Compound-#
Property
Variable
Constraint
Phase
Method
#Points
POMD
1
Normal melting temperature, K ; Crystal
Crystal
Liquid
Air at 1 atmosphere
DTA
1
POMD
1
Molar enthalpy of transition or fusion, kJ/mol ; Crystal