Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Standard Thermodynamic Functions of Tripeptides N-Formyl-l-methionyl-l-leucyl-l-phenylalaninol and N-Formyl-l-methionyl-l-leucyl-l-phenylalanine Methyl Ester

Markin, A. V.[Alexey V.], Markhasin, E.[Evgeny], Sologubov, S. S.[Semen S.], Smirnova, N. N.[Natalia N.], Griffin, R. G.[Robert G.]
J. Chem. Eng. Data 2014, 59, 4, 1240-1246
ABSTRACT
The heat capacities of tripeptides N-formyl-l-methionyl-l-leucyl-l-phenylalaninol (N-f-MLF-OH) and N-formyl-l-methionyl-l-leucyl-l-phenylalanine methyl ester (N-f-MLF-OMe) were measured by precision adiabatic vacuum calorimetry over the temperature range from T = (6 to 350) K. The tripeptides were stable over this temperature range, and no phase change, transformation, association, or thermal decomposition was observed. The standard thermodynamic functions: molar heat capacity Cp,m, enthalpy H(T) H(0), entropy S(T), and Gibbs energy G(T) H(0) of peptides were calculated over the range from T = (0 to 350) K. The low-temperature (T = 50 K) heat capacities dependencies were analyzed using the Debye s and the multifractal theories. The standard entropies of formation of peptides at T = 298.15 K were calculated.
Compounds
# Formula Name
1 C21H31N3O5S N-formyl-L-methionyl-L-leucyl-L-phenylalanine
2 C22H33N3O5S methyl formyl-L-methionyl-L-leucyl-L-phenylalaninate
Datasets
The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type Compound-# Property Variable Constraint Phase Method #Points
  • POMD
  • 1
  • Molar heat capacity at constant pressure, J/K/mol ; Crystal
  • Temperature, K; Crystal
  • Pressure, kPa; Crystal
  • Crystal
  • SMALLAD:UFactor:4
  • 157
  • POMD
  • 1
  • Molar heat capacity at constant pressure, J/K/mol ; Crystal
  • Temperature, K; Crystal
  • Pressure, kPa; Crystal
  • Crystal
  • SMALLAD:UFactor:4
  • 39
  • POMD
  • 1
  • Molar enthalpy, kJ/mol ; Crystal
  • Temperature, K; Crystal
  • Pressure, kPa; Crystal
  • Crystal
  • SMALLAD:UFactor:4
  • 39
  • POMD
  • 1
  • Molar entropy, J/K/mol ; Crystal
  • Temperature, K; Crystal
  • Pressure, kPa; Crystal
  • Crystal
  • SMALLAD:UFactor:4
  • 39
  • POMD
  • 2
  • Molar heat capacity at constant pressure, J/K/mol ; Crystal
  • Temperature, K; Crystal
  • Pressure, kPa; Crystal
  • Crystal
  • SMALLAD:UFactor:2
  • 185
  • POMD
  • 2
  • Molar heat capacity at constant pressure, J/K/mol ; Crystal
  • Temperature, K; Crystal
  • Pressure, kPa; Crystal
  • Crystal
  • SMALLAD:UFactor:2
  • 39
  • POMD
  • 2
  • Molar enthalpy, kJ/mol ; Crystal
  • Temperature, K; Crystal
  • Pressure, kPa; Crystal
  • Crystal
  • SMALLAD:UFactor:2
  • 39
  • POMD
  • 2
  • Molar entropy, J/K/mol ; Crystal
  • Temperature, K; Crystal
  • Pressure, kPa; Crystal
  • Crystal
  • SMALLAD:UFactor:2
  • 39