The solubility of cefpiramide sodium in binary solvent mixtures of ethanol + water and 2-propanol + water was determined by a steady-state method from (278.2 to 303.2) K and in the initial mole fraction range of alcohol (ethanol or 2-propanol) in the solvent mixture at about 0.4 to 0.8. Cefpiramide sodium exhibits the same order of magnitude of solubility in both binary systems. The solubility decreases with the increase of the initial mole fraction of alcohol and increases with increasing temperature. Dilution crystallization or dilution crystallization incorporated with cooling crystallization will be more suitable than pure cooling crystallization for the purification of cefpiramide sodium. The Jouyban Acree model, combined with the van t Hoff equation, was used to correlate the solubility data. The combined model was further simplified so that each item in the model is statistically significant at the 5 % level. The simplified combined model gives a mean relative deviation of 5.3 % for the ethanol + water system, and 3.0 % for the 2-propanol + water system. This model demonstrates good fitting with the experimental solubility data, and could be used for related process design in the pharmaceutical industry.
Compounds
#
Formula
Name
1
C25H23N8NaO7S2
Cefpiramide sodium
2
C2H6O
ethanol
3
C3H8O
propan-2-ol
4
H2O
water
Datasets
The table above is generated from the ThermoML associated json file (link above).
POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied;
the numbers refer to the table of compounds on the left.