ABSTRACT

Solubility values of 20 hydrazones in water, 1-octanol and hexane were determined by the isothermal saturation method. Thermophysical characteristics of fusion processes (melting points and fusion enthalpies) of the selected substances were measured by DSC method. The impact of structural modification of the molecules on solubility processes in the solvents was analyzed. Transfer processes from water to 1-octanol and from water to hexane were analyzed. Correlation equations connecting the transfer coefficients with physicochemical descriptors were obtained.

Compounds

#	Formula	Name
1	C15H12N4	2-pyridinecarboxaldehyde, 2-(2-quinolinyl)hydrazone
2	C11H10N4	2-pyridinecarboxaldehyde, 2-(2-pyridinyl)hydrazone
3	C10H8ClN5	2-pyridinecarboxaldehyde, 2-(6-chloro-4-pyrimidinyl)hydrazone
4	C11H9ClN4O	ethanone, 1-(2-pyridinyl)-, O-(6-chloro-4-pyrimidinyl)oxime
5	C12H11N3	benzaldehyde, 2-(2-pyridinyl)hydrazone
6	C12H11N3	2-pyridinecarboxaldehyde, 2-phenylhydrazone
7	C11H10N4	3-pyridinecarboxaldehyde, 2-(2-pyridinyl)hydrazone
8	C17H15N7	2,6-pyridinedicarboxaldehyde, 2,6-bis[2-(2-pyridinyl)hydrazone]
9	C16H14N4	ethanone, 1-(2-pyridinyl)-, 2-(2-quinolinyl)hydrazone
10	C21H17N5O	2-pyridinecarboxaldehyde, 5-(phenylmethoxy)-, 2-(1-phthalazinyl)hydrazone
11	C22H17N3	benzophenone, 2-quinolylhydrazone
12	C16H15N5	1-propanone, 1-(2-pyridinyl)-, 2-(1-phthalazinyl)hydrazone
13	C15H13N5	ethanone, 1-(2-pyridinyl)-, 2-(1-phthalazinyl)hydrazone
14	C16H12ClN5	methanone, phenyl-2-pyridinyl-, 2-(6-chloro-3-pyridazinyl)hydrazone
15	C16H12ClN5	methanone, phenyl-2-pyridinyl-, 2-(6-chloro-4-pyrimidinyl)hydrazone
16	C17H14ClN5O	2-pyridinecarboxaldehyde, 5-(phenylmethoxy)-, 2-(6-chloro-4-pyrimidinyl)hydrazone
17	C11H10ClN5	ethanone, 1-(2-pyridinyl)-, 2-(6-chloro-4-pyrimidinyl)hydrazone
18	C12H12ClN5	1-propanone, 1-(2-pyridinyl)-, 2-(6-chloro-4-pyrimidinyl)hydrazone
19	C18H16N4O	2-pyridinecarboxaldehyde, 5-(phenylmethoxy)-, 2-(2-pyridinyl)hydrazone
20	C21H17N5O	2-pyridinecarboxaldehyde, 5-(phenylmethoxy)-, 2-(4-quinazolinyl)hydrazone
21	H2O	water
22	C8H18O	octan-1-ol
23	C6H14	hexane

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Phase	Method	#Points
POMD	1	Normal melting temperature, K ; Crystal		Crystal Liquid Air at 1 atmosphere	DTA	1
POMD	1	Molar enthalpy of transition or fusion, kJ/mol ; Crystal		Crystal Liquid Air at 1 atmosphere	DSC	1
POMD	2	Normal melting temperature, K ; Crystal		Crystal Liquid Air at 1 atmosphere	DTA	1
POMD	2	Molar enthalpy of transition or fusion, kJ/mol ; Crystal		Crystal Liquid Air at 1 atmosphere	DSC	1
POMD	3	Normal melting temperature, K ; Crystal		Crystal Liquid Air at 1 atmosphere	DTA	1
POMD	3	Molar enthalpy of transition or fusion, kJ/mol ; Crystal		Crystal Liquid Air at 1 atmosphere	DSC	1
POMD	4	Normal melting temperature, K ; Crystal		Crystal Liquid Air at 1 atmosphere	DTA	1
POMD	4	Molar enthalpy of transition or fusion, kJ/mol ; Crystal		Crystal Liquid Air at 1 atmosphere	DSC	1
POMD	5	Normal melting temperature, K ; Crystal		Crystal Liquid Air at 1 atmosphere	DTA	1
POMD	5	Molar enthalpy of transition or fusion, kJ/mol ; Crystal		Crystal Liquid Air at 1 atmosphere	DSC	1
POMD	6	Normal melting temperature, K ; Crystal		Crystal Liquid Air at 1 atmosphere	DTA	1
POMD	6	Molar enthalpy of transition or fusion, kJ/mol ; Crystal		Crystal Liquid Air at 1 atmosphere	DSC	1
POMD	7	Normal melting temperature, K ; Crystal		Crystal Liquid Air at 1 atmosphere	DTA	1
POMD	7	Molar enthalpy of transition or fusion, kJ/mol ; Crystal		Crystal Liquid Air at 1 atmosphere	DSC	1
POMD	9	Normal melting temperature, K ; Crystal		Crystal Liquid Air at 1 atmosphere	DTA	1
POMD	9	Molar enthalpy of transition or fusion, kJ/mol ; Crystal		Crystal Liquid Air at 1 atmosphere	DSC	1
POMD	10	Normal melting temperature, K ; Crystal		Crystal Liquid Air at 1 atmosphere	DTA	1
POMD	10	Molar enthalpy of transition or fusion, kJ/mol ; Crystal		Crystal Liquid Air at 1 atmosphere	DSC	1
POMD	11	Normal melting temperature, K ; Crystal		Crystal Liquid Air at 1 atmosphere	DTA	1
POMD	11	Molar enthalpy of transition or fusion, kJ/mol ; Crystal		Crystal Liquid Air at 1 atmosphere	DSC	1
POMD	12	Normal melting temperature, K ; Crystal		Crystal Liquid Air at 1 atmosphere	DTA	1
POMD	12	Molar enthalpy of transition or fusion, kJ/mol ; Crystal		Crystal Liquid Air at 1 atmosphere	DSC	1
POMD	13	Normal melting temperature, K ; Crystal		Crystal Liquid Air at 1 atmosphere	DTA	1
POMD	13	Molar enthalpy of transition or fusion, kJ/mol ; Crystal		Crystal Liquid Air at 1 atmosphere	DSC	1
POMD	14	Normal melting temperature, K ; Crystal		Crystal Liquid Air at 1 atmosphere	DTA	1
POMD	14	Molar enthalpy of transition or fusion, kJ/mol ; Crystal		Crystal Liquid Air at 1 atmosphere	DSC	1
POMD	15	Normal melting temperature, K ; Crystal		Crystal Liquid Air at 1 atmosphere	DTA	1
POMD	15	Molar enthalpy of transition or fusion, kJ/mol ; Crystal		Crystal Liquid Air at 1 atmosphere	DSC	1
POMD	16	Normal melting temperature, K ; Crystal		Crystal Liquid Air at 1 atmosphere	DTA	1
POMD	16	Molar enthalpy of transition or fusion, kJ/mol ; Crystal		Crystal Liquid Air at 1 atmosphere	DSC	1
POMD	17	Normal melting temperature, K ; Crystal		Crystal Liquid Air at 1 atmosphere	DTA	1
POMD	17	Molar enthalpy of transition or fusion, kJ/mol ; Crystal		Crystal Liquid Air at 1 atmosphere	DSC	1
POMD	18	Normal melting temperature, K ; Crystal		Crystal Liquid Air at 1 atmosphere	DTA	1
POMD	18	Molar enthalpy of transition or fusion, kJ/mol ; Crystal		Crystal Liquid Air at 1 atmosphere	DSC	1
POMD	19	Normal melting temperature, K ; Crystal		Crystal Liquid Air at 1 atmosphere	DTA	1
POMD	19	Molar enthalpy of transition or fusion, kJ/mol ; Crystal		Crystal Liquid Air at 1 atmosphere	DSC	1
POMD	20	Normal melting temperature, K ; Crystal		Crystal Liquid Air at 1 atmosphere	DTA	1
POMD	20	Molar enthalpy of transition or fusion, kJ/mol ; Crystal		Crystal Liquid Air at 1 atmosphere	DSC	1
POMD	1 21	Molality, mol/kg - 1 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 1	Spectroscopy	1
POMD	2 21	Molality, mol/kg - 2 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 2	Spectroscopy	1
POMD	21 3	Molality, mol/kg - 3 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 3	Spectroscopy	1
POMD	21 4	Molality, mol/kg - 4 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 4	Spectroscopy	1
POMD	5 21	Molality, mol/kg - 5 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 5	Spectroscopy	1
POMD	6 21	Molality, mol/kg - 6 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 6	Spectroscopy	1
POMD	21 7	Molality, mol/kg - 7 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 7	Spectroscopy	1
POMD	21 8	Molality, mol/kg - 8 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 8	Spectroscopy	1
POMD	21 9	Molality, mol/kg - 9 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 9	Spectroscopy	1
POMD	21 10	Molality, mol/kg - 10 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 10	Spectroscopy	1
POMD	21 11	Molality, mol/kg - 11 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 11	Spectroscopy	1
POMD	21 12	Molality, mol/kg - 12 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 12	Spectroscopy	1
POMD	21 13	Molality, mol/kg - 13 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 13	Spectroscopy	1
POMD	21 14	Molality, mol/kg - 14 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 14	Spectroscopy	1
POMD	21 15	Molality, mol/kg - 15 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 15	Spectroscopy	1
POMD	21 16	Molality, mol/kg - 16 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 16	Spectroscopy	1
POMD	21 17	Molality, mol/kg - 17 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 17	Spectroscopy	1
POMD	21 18	Molality, mol/kg - 18 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 18	Spectroscopy	1
POMD	21 19	Molality, mol/kg - 19 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 19	Spectroscopy	1
POMD	21 20	Molality, mol/kg - 20 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 20	Spectroscopy	1
POMD	22 1	Molality, mol/kg - 1 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 1	Spectroscopy	1
POMD	22 2	Molality, mol/kg - 2 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 2	Spectroscopy	1
POMD	22 3	Molality, mol/kg - 3 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 3	Spectroscopy	1
POMD	22 4	Molality, mol/kg - 4 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 4	Spectroscopy	1
POMD	22 5	Molality, mol/kg - 5 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 5	Spectroscopy	1
POMD	22 6	Molality, mol/kg - 6 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 6	Spectroscopy	1
POMD	22 7	Molality, mol/kg - 7 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 7	Spectroscopy	1
POMD	22 8	Molality, mol/kg - 8 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 8	Spectroscopy	1
POMD	22 9	Molality, mol/kg - 9 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 9	Spectroscopy	1
POMD	22 10	Molality, mol/kg - 10 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 10	Spectroscopy	1
POMD	22 11	Molality, mol/kg - 11 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 11	Spectroscopy	1
POMD	22 12	Molality, mol/kg - 12 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 12	Spectroscopy	1
POMD	22 13	Molality, mol/kg - 13 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 13	Spectroscopy	1
POMD	22 14	Molality, mol/kg - 14 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 14	Spectroscopy	1
POMD	22 15	Molality, mol/kg - 15 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 15	Spectroscopy	1
POMD	22 16	Molality, mol/kg - 16 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 16	Spectroscopy	1
POMD	22 17	Molality, mol/kg - 17 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 17	Spectroscopy	1
POMD	22 18	Molality, mol/kg - 18 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 18	Spectroscopy	1
POMD	22 19	Molality, mol/kg - 19 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 19	Spectroscopy	1
POMD	22 20	Molality, mol/kg - 20 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 20	Spectroscopy	1
POMD	23 1	Molality, mol/kg - 1 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 1	Spectrsocopy	1
POMD	23 2	Molality, mol/kg - 2 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 2	Spectrsocopy	1
POMD	23 3	Molality, mol/kg - 3 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 3	Spectrsocopy	1
POMD	23 4	Molality, mol/kg - 4 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 4	Spectrsocopy	1
POMD	23 5	Molality, mol/kg - 5 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 5	Spectrsocopy	1
POMD	23 6	Molality, mol/kg - 6 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 6	Spectrsocopy	1
POMD	23 7	Molality, mol/kg - 7 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 7	Spectrsocopy	1
POMD	23 8	Molality, mol/kg - 8 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 8	Spectrsocopy	1
POMD	23 9	Molality, mol/kg - 9 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 9	Spectrsocopy	1
POMD	23 10	Molality, mol/kg - 10 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 10	Spectrsocopy	1
POMD	23 11	Molality, mol/kg - 11 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 11	Spectrsocopy	1
POMD	23 12	Molality, mol/kg - 12 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 12	Spectrsocopy	1
POMD	23 13	Molality, mol/kg - 13 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 13	Spectrsocopy	1
POMD	23 14	Molality, mol/kg - 14 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 14	Spectrsocopy	1
POMD	23 15	Molality, mol/kg - 15 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 15	Spectrsocopy	1
POMD	23 16	Molality, mol/kg - 16 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 16	Spectrsocopy	1
POMD	23 17	Molality, mol/kg - 17 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 17	Spectrsocopy	1
POMD	23 18	Molality, mol/kg - 18 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 18	Spectrsocopy	1
POMD	23 19	Molality, mol/kg - 19 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 19	Spectrsocopy	1
POMD	23 20	Molality, mol/kg - 20 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 20	Spectrsocopy	1

Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Solubility and Transfer Processes of Some Hydrazones in Biologically Relevant Solvents

Perlovich, G. L.[German L.], Kazachenko, V. P.[Vladimir P.], Strakhova, N. N.[Nadezda N.], Schaper, K.-J.[Klaus-J.], Raevsky, O. A.[Oleg A.]

ABSTRACT