ABSTRACT

The study of the solubility of important biomolecules such as flavonoids is essential to support the design of several separation processes in the food and pharmaceutical industries. Following our previous studies, new solubility data of hesperetin in the mixed solvents water + acetone, water + ethanol, and water + methanol were measured, at 298.2 K, by the isothermal shake-flask method. The results obtained show three solid liquid phase diagrams with distinct features. Additionally, the solid crystals obtained from the solubility studies were analyzed by powder X-ray diffraction, infrared spectroscopy, and thermogravimetric analysis indicating that, depending on the mixed solvents composition, two different crystal structures of hesperetin, already described in the literature, can be obtained, corresponding either to the anhydrous or the monohydrate forms.

Compounds

#	Formula	Name
1	C16H14O6	2,3-Dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one
2	H2O	water
3	C3H6O	acetone
4	C2H6O	ethanol
5	CH4O	methanol

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	5 1 2	Molality, mol/kg - 1 ; Liquid	Solvent: Mole fraction - 5; Liquid	Pressure, kPa; Liquid Temperature, K; Liquid	Liquid Crystal of intercomponent compound 1	Gravimetric method	3
POMD	5 1 2	Molality, mol/kg - 1 ; Liquid	Solvent: Molality, mol/kg - 5; Liquid	Pressure, kPa; Liquid Temperature, K; Liquid	Liquid Crystal - 1	uih	8
POMD	4 1 2	Molality, mol/kg - 1 ; Liquid	Solvent: Mole fraction - 4; Liquid	Pressure, kPa; Liquid Temperature, K; Liquid	Liquid Crystal of intercomponent compound 1	Gravimetric method	5
POMD	4 1 2	Molality, mol/kg - 1 ; Liquid	Solvent: Molality, mol/kg - 4; Liquid	Pressure, kPa; Liquid Temperature, K; Liquid	Liquid Crystal - 1	uih	10
POMD	3 1 2	Molality, mol/kg - 1 ; Liquid	Solvent: Mole fraction - 3; Liquid	Pressure, kPa; Liquid Temperature, K; Liquid	Liquid Crystal of intercomponent compound 1	Gravimetric method	11
POMD	3 1 2	Molality, mol/kg - 1 ; Liquid	Solvent: Molality, mol/kg - 3; Liquid	Pressure, kPa; Liquid Temperature, K; Liquid	Liquid Crystal - 1	uih	3

Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Solubility of Hesperetin in Mixed Solvents

Ferreira, O.[Olga], Schroder, B.[Bernd], Pinho, S. P.[Simao P.]

ABSTRACT