Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

ABSTRACT

Vapor pressures, vaporization, and sublimation enthalpies of several pharmaceuticals have been evaluated by a combination of correlation chromatography experiments, differential calorimetry measurements with existing literature values. The compounds investigated and their properties include 1-adamantylamine [?crlHm(Tfus)/kJ*mol 1 = (7.3 +- 0.2); Tfus/K = (477.4 +- 0.9); ?lgHm(298.15 K)/kJ*mol 1 = (59.9 +- 2.5); ?crgHm(298.15 K)/kJ*mol 1 = (59.9 +- 3.5); p(l)/Pa = (21 +- 1); p(cr)/Pa = (11.5 +- 2.1)]; 1-adamantyl-ethanamine, [?lgHm(298.15 K)/kJ*mol 1 = (68.7 +- 3.7); p(l)/Pa = (3 +- 1)]; a,a-dimethylphenethylamine [?lgHm(298.15 K)/kJ*mol 1 = (60.2 +- 2.6); p(l)/Pa = (35 +- 4)]; trans 2-phenylcyclopropylamine [?lgHm(298.15 K)/kJ*mol 1 = (60.3 +- 2.1), p(l)/Pa = (28 +- 5)]; 1-dodecanamine [?crgHm(298.15 K)/kJ*mol 1 = (118.3 +- 1.8); p(cr)/Pa = 1.6 +- 0.1]; and 1-tetradecanamine [?crgHm(298.15 K)/kJ*mol 1 = (134.5 +- 2.1); p(cr)/Pa = 0.12 +- 0.04]. Vapor pressure equations also derived from vapor pressure retention time correlations as a function of temperature are reported for both standards and targets. The equations appear applicable from T/K = 298.15 to each compound s respective boiling temperature.