The solubility of cefradine form I in five pure solvents from (283.15 to 308.15) K was experimentally determined by using an equilibrium method. It was found that the solubility of cefradine form I in all tested solvents increased with the increase of temperature. Four thermodynamic models were used to correlate the experimental solubility data. The infinite-dilution activity coefficient and mixing properties including the mixing free Gibbs energy, enthalpy, and entropy of cefradine form I solution were also calculated by using the nonrandom two-liquid (NRTL) model. It was found that the correlated results by the van t Hoff equation, the modified Apelblat equation, and the NRTL model agreed well with the experimental data.
Compounds
#
Formula
Name
1
C16H19N3O4S
Cefradin
2
CH4O
methanol
3
C2H6O
ethanol
4
C3H8O
propan-1-ol
5
C4H10O
butan-1-ol
6
H2O
water
Datasets
The table above is generated from the ThermoML associated json file (link above).
POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied;
the numbers refer to the table of compounds on the left.