Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Solubility of Dexamethasone in Supercritical Carbon Dioxide

Chim, R. B., de Matos, M. B. C., Braga, M. E. M., Dias, A. M. A., de Sousa, H. C.
J. Chem. Eng. Data 2012, 57, 12, 3756-3760
ABSTRACT
Dexamethasone (DXMT) is a glucocorticoid that belongs to an important class of synthetic steroid hormones with potential to treat chronic immune and inflammatory diseases. In this work, the solid solubility of dexamethasone in supercritical carbon dioxide (scCO2) was measured using a static method. Experimental data were measured at (308.2, 318.2, and 328.2) K in the pressure range from (15.1 to 35.7) MPa. The solubility in scCO2 was found to be low and between (1.25*10 6 or 9.1*10 3) kg*m 3 (at 308.2 K and 15.1 MPa) and (2.81*10 6 or 22.0*10 3) kg*m 3 (at 328.2 K and 34.8 MPa) in terms of mole fraction or mass of drug per volume of solvent, respectively. Experimental data were correlated using semiempirical density based models (Mendez-Santiago Teja, Bartle, and Chrastil). Obtained average absolute relative deviation [AARD (%)] values were lower than 13 %
Compounds
# Formula Name
1 CO2 carbon dioxide
2 C22H29FO5 (11.beta.,16.alpha.)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1.4-diene-3,20-dione
Datasets
The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type Compound-# Property Variable Constraint Phase Method #Points
  • POMD
  • 2
  • 1
  • Mole fraction - 2 ; Fluid (supercritical or subcritical phases)
  • Temperature, K; Fluid (supercritical or subcritical phases)
  • Pressure, kPa; Fluid (supercritical or subcritical phases)
  • Fluid (supercritical or subcritical phases)
  • Crystal - 2
  • HPLC
  • 15