Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Solubility and Induction Period Study of Asiaticoside and Madecassoside in a Methanol + Water Mixture

Zheng, X.-F.[Xing-Fang], Fu, J.[Jie], Lu, X.-Y.[Xiu-Yang]
J. Chem. Eng. Data 2012, 57, 11, 3258-3263
ABSTRACT
The solubilities of madecassoside in a mixture of methanol + water were determined in the temperature range from (298.15 to 328.15) K by a static analytical method. A W -type curve was found for the solubility of madecassoside in the mixture of methanol + water. The induction periods of asiaticoside and madecassoside in a mixture of methanol + water were determined at 298.15 K by a laser scattering method. The results show that the solubilities of madecassoside are similar to those of asiaticoside in the mixture of methanol water excluding those at high water content and high temperature. However, these two compounds with the only difference of 6-OH exhibit a quite different crystallization property that the induction period of madecassoside is at least 10 times longer than asiaticoside. Moreover, the interfacial tension data of asiaticoside were obtained, which are in the range of (0.55 to 0.86) mJ*m 2.
Compounds
# Formula Name
1 C48H78O20 madecassoside
2 CH4O methanol
3 H2O water
Datasets
The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type Compound-# Property Variable Constraint Phase Method #Points
  • POMD
  • 2
  • 3
  • 1
  • Mole fraction - 1 ; Liquid
  • Temperature, K; Liquid
  • Solvent: Mole fraction - 2; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 1
  • Chromatography
  • 128