Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Measurement and Correlation of the Solubility of Febuxostat in Four Organic Solvents at Various Temperatures

Zhang, L.[Lei], Huang, Z.[Zhiping], Wan, X.[Xiaoran], Li, J.[Jing], Liu, J.[Jing]
J. Chem. Eng. Data 2012, 57, 11, 3149-3152
ABSTRACT
The solubility of febuxostat in ethyl acetate, methanol, ethanol, and acetone was determined respectively by the gravimetric method from (293.15 to 328.15) K under atmospheric pressure, and the experimental data were well-correlated by the Apelblat and van t Hoff equations. The experimental solubility data and their correlation equation obtained would be useful for the solvent selection of febuxostat crystallization.
Compounds
# Formula Name
1 C4H8O2 ethyl acetate
2 CH4O methanol
3 C2H6O ethanol
4 C3H6O acetone
5 C16H16N2O3S 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid
6 H2O water
7 ClNa sodium chloride
Datasets
The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type Compound-# Property Variable Constraint Phase Method #Points
  • POMD
  • 7
  • 6
  • Mass ratio of solute to solvent ; Liquid
  • Temperature, K; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 7
  • Gravimetric
  • 5
  • POMD
  • 1
  • 5
  • Mole fraction - 5 ; Liquid
  • Temperature, K; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 5
  • Gravimetric
  • 8
  • POMD
  • 3
  • 5
  • Mole fraction - 5 ; Liquid
  • Temperature, K; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 5
  • Gravimetric
  • 8
  • POMD
  • 4
  • 5
  • Mole fraction - 5 ; Liquid
  • Temperature, K; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 5
  • Gravimetric
  • 8
  • POMD
  • 2
  • 5
  • Mole fraction - 5 ; Liquid
  • Temperature, K; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 5
  • Gravimetric
  • 8