ABSTRACT

The volumetric and acoustic methods are used for investigating the interactions of l-serine with drugs ampicillin (AMP) and amoxicillin (AMX) as a function of temperature. Densities and speeds of sound of l-serine in (0.0009, 0.0018, 0.0028, and 0.0038) mol*kg 1 solutions of ampicillin and amoxicillin have been measured at T = (305.15, 310.15, and 315.15) K and atmospheric pressure. The density and speed of sound data have been used to determine apparent molar volume (V) and apparent molar adiabatic compressibility (K,s). The positive values of V and negative values of K,s indicate attractive interactions between l-serine and drug molecules. The pair interaction and triplet interaction coefficient for volumetric and acoustic data have also been calculated which suggest pairwise interactions between l-serine and drug molecules. The results have been discussed in terms of various interactions prevailing in aqueous solutions of amino acids and drugs.

Compounds

#	Formula	Name
1	C16H19N3O4S	6-[D-(2-amino-2-phenylacetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
2	C16H19N3O5S	amoxicillin
3	C3H7NO3	L-serine
4	H2O	water

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	3 1 4	Speed of sound, m/s ; Liquid	Solvent: Molality, mol/kg - 1; Liquid Temperature, K; Liquid Molality, mol/kg - 3; Liquid	Pressure, kPa; Liquid	Liquid	Sing-around technique in a fixed-path interferometer	147
POMD	3 1 4	Mass density, kg/m3 ; Liquid	Solvent: Molality, mol/kg - 1; Liquid Temperature, K; Liquid Molality, mol/kg - 3; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	147
POMD	3 4 2	Speed of sound, m/s ; Liquid	Solvent: Molality, mol/kg - 2; Liquid Temperature, K; Liquid Molality, mol/kg - 3; Liquid	Pressure, kPa; Liquid	Liquid	Sing-around technique in a fixed-path interferometer	108
POMD	3 4 2	Mass density, kg/m3 ; Liquid	Solvent: Molality, mol/kg - 2; Liquid Temperature, K; Liquid Molality, mol/kg - 3; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	108

Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Densities and Speeds of Sound of l-Serine with Aqueous Solutions of Antibacterial Drugs at Different Temperatures

Kumar, H.[Harsh], Kaur, K.[Kirtanjot]

ABSTRACT