Solubility of 3-Ethyl-5-methyl-(4RS)-2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate Monobenzenesulfonate (Amlodipine Besylate) in Ethanol + Water and Propane-1,2-diol + Water Mixtures at Various Temperatures
Solubilities of amlodipine besylate (AMB) in binary mixtures of ethanol (EtOH) + water and propane-1,2-diol or propylene glycol (PG) + water at (293.2, 298.2, 303.2, 308.2, and 313.2) K at atmospheric pressure are reported. In the EtOH + water system, the maximum mole fraction solubility of AMB was observed at 313.2 K and an EtOH mass fraction of 0.65. The corresponding value for PG + water mixtures was obtained in a PG mass fraction of 0.80 at 313.2 K. A combination of the Jouyban Acree model and van t Hoff equation was used to predict the solubility of AMB in the mixed solvents at different temperatures. A mean relative deviation of 13.5 % was obtained for the correlated data. The generated solubility data and the derived computations could be used in the pharmaceutical industry where such information is required to speed up the process design.
Compounds
#
Formula
Name
1
C2H6O
ethanol
2
H2O
water
3
C26H31ClN2O8S
amlodipine benzenesulfonate
4
C3H8O2
1,2-propanediol
Datasets
The table above is generated from the ThermoML associated json file (link above).
POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied;
the numbers refer to the table of compounds on the left.