Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Solubility of Vitamin D3 in Six Organic Solvents at Temperatures from (248.2 to 273.2) K

Liang, R.[Ruisi], Bao, Z.[Zongbi], Su, B.[Baogen], Xing, H.[Huabin], Ren, Q.[Qilong]
J. Chem. Eng. Data 2012, 57, 8, 2328-2331
ABSTRACT
The solubility of Vitamin D3 in methanol, ethanenitrile, ethyl ethanoate, ethanol, propan-2-one, and propan-1-ol was measured in the temperature range from (248.2 to 273.2) K by the static equilibrium method. The results revealed that the solubility of Vitamin D3 in solvents was observed to decrease in the order of propan-1-ol greater than ethanol greater than ethyl ethanoate greater than propan-2-one greater than methanol greater than ethanenitrile. The minimum mole fraction solubility of 7.61*10 5 was obtained in ethanenitrile at 248.2 K, while the maximum mole fraction solubility up to 0.193 was obtained in propan-1-ol at 273.2 K. Moreover, the solubility data were correlated with the simplified thermodynamic equation and the modified Apelblat equation, and the calculated solubility for all solvents above was in good agreement with the experimental data in the temperature range of interest.
Compounds
# Formula Name
1 CH4O methanol
2 C27H44O (3S,5Z,7E)-9,10-secocholesta-5,7,10-trien-3-ol
3 C2H6O ethanol
4 C2H3N acetonitrile
5 C3H6O acetone
6 C4H8O2 ethyl acetate
7 C3H8O propan-1-ol
Datasets
The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type Compound-# Property Variable Constraint Phase Method #Points
  • POMD
  • 1
  • 2
  • Mole fraction - 2 ; Liquid
  • Temperature, K; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 2
  • Chromatography
  • 6
  • POMD
  • 3
  • 2
  • Mole fraction - 2 ; Liquid
  • Temperature, K; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 2
  • Chromatography
  • 6
  • POMD
  • 2
  • 4
  • Mole fraction - 2 ; Liquid
  • Temperature, K; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 2
  • Chromatography
  • 6
  • POMD
  • 5
  • 2
  • Mole fraction - 2 ; Liquid
  • Temperature, K; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 2
  • Chromatography
  • 6
  • POMD
  • 2
  • 6
  • Mole fraction - 2 ; Liquid
  • Temperature, K; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 2
  • Chromatography
  • 6
  • POMD
  • 2
  • 7
  • Mole fraction - 2 ; Liquid
  • Temperature, K; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 2
  • Chromatography
  • 6