ABSTRACT

The solubilities of amiodarone HCl (AMDH) in binary mixtures of ethanol + water and N-methyl pyrrolidone (NMP) + water at (293.2, 298.2, 303.2, 308.2, and 313.2) K are reported. In the ethanol + water system the maximum solubility of AMDH was observed at 313.2 K and an ethanol mass fraction of 0.76. The combination of the Jouyban Acree model and van't Hoff equation was used to predict the solubility of AMDH in the mixed solvents at different temperatures. A mean relative deviation of 12.2 % was obtained for the correlated data. The standard enthalpy, entropy ,and Gibbs energy changes of solutions for AMDH in ethanol + water and NMP + water mixtures were calculated from the measured solubility data using the modified version of the van't Hoff equation.

Compounds

#	Formula	Name
1	C2H6O	ethanol
2	C25H30ClI2NO3	2-butyl-3-benzofuranyl 4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone hydrochloride
3	H2O	water
4	C5H9NO	N-methylpyrrolidone

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	1 2	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 2	Pycnometric method	5
POMD	1 2	Mole fraction - 2 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 2	Spectrophotometrical Assay	5
POMD	2 3	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 2	Pycnometric method	5
POMD	2 3	Mole fraction - 2 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 2	Spectrophotometrical Assay	7
POMD	4 2	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 2	Pycnometric method	5
POMD	4 2	Mole fraction - 2 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 2	Spectrophotometrical Assay	5
POMD	1 2 3	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Solvent: Mass fraction - 3; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 2	Pycnometric method	55
POMD	1 2 3	Mole fraction - 2 ; Liquid	Temperature, K; Liquid Solvent: Mass fraction - 3; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 2	Spectrophotometrical Assay	55
POMD	4 2 3	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Solvent: Mass fraction - 3; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 2	Pycnometric method	55
POMD	4 2 3	Mole fraction - 2 ; Liquid	Temperature, K; Liquid Solvent: Mass fraction - 3; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 2	Spectrophotometrical Assay	55

Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Solubility of 2-Butyl-3-benzofuranyl 4-(2-(Diethylamino)ethoxy)-3,5-diiodophenyl Ketone Hydrochloride (Amiodarone HCl) in Ethanol + Water and N-Methyl-2-pyrrolidone + Water Mixtures at Various Temperatures

Eghrary, S.[Shadi], Zarghami, R.[Reza], Martinez, F.[Fleming], Jouyban, A.[Abolghasem]

ABSTRACT