ABSTRACT

The solubilities of forms I and II of clopidogrel hydrogen sulfate (CHS) were measured in solvents such as formic acid (FA), N-methylpyrrolidone (NMP), and N,N-dimethylformamide (DMFA) at a temperature range of (283.15 to 353.15) K. The solubilities of forms I and II of CHS in FA + propan-2-ol, NMP + propan-2-ol, and DMFA + propan-2-ol were measured at a temperature of 308.15 K and various propan-2-ol mass fractions. The enthalpy and entropy of dissolution of CHS forms I and II of CHS in pure solvents were determined by using the van't Hoff equation.

Compounds

#	Formula	Name
1	CH2O2	formic acid
2	C16H18ClNO6S2	(S)-(+)-Clopidogrel hydrogen sulfate
3	C5H9NO	N-methylpyrrolidone
4	C3H7NO	dimethylformamide
5	C3H8O	propan-2-ol

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	1 2	Mass ratio of solute to solvent - 2 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal 2 - 2	titration method	5
POMD	1 2	Mass ratio of solute to solvent - 2 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal 1 - 2	titration method	5
POMD	3 2	Mass ratio of solute to solvent - 2 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal 2 - 2	titration method	5
POMD	3 2	Mass ratio of solute to solvent - 2 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal 1 - 2	titration method	5
POMD	4 2	Mass ratio of solute to solvent - 2 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal 1 - 2	titration method	6
POMD	4 2	Mass ratio of solute to solvent - 2 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal 2 - 2	titration method	6
POMD	5 2	Mass ratio of solute to solvent - 2 ; Liquid	Pressure, kPa; Liquid Temperature, K; Liquid		Liquid Crystal 2 - 2	titration method	1
POMD	5 2	Mass ratio of solute to solvent - 2 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid		Liquid Crystal 1 - 2	titration method	1
POMD	1 5 2	Mass ratio of solute to solvent - 2 ; Liquid	Solvent: Mass fraction - 1; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal 2 - 2	titration method	5
POMD	1 5 2	Mass ratio of solute to solvent - 2 ; Liquid	Solvent: Mass fraction - 1; Liquid	Pressure, kPa; Liquid Temperature, K; Liquid	Liquid Crystal 1 - 2	titration method	5
POMD	5 3 2	Mass ratio of solute to solvent - 2 ; Liquid	Solvent: Mass fraction - 3; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal 2 - 2	titration method	5
POMD	5 3 2	Mass ratio of solute to solvent - 2 ; Liquid	Solvent: Mass fraction - 3; Liquid	Pressure, kPa; Liquid Temperature, K; Liquid	Liquid Crystal 1 - 2	titration method	5
POMD	5 4 2	Mass ratio of solute to solvent - 2 ; Liquid	Solvent: Mass fraction - 4; Liquid	Pressure, kPa; Liquid Temperature, K; Liquid	Liquid Crystal 2 - 2	titration method	5
POMD	5 4 2	Mass ratio of solute to solvent - 2 ; Liquid	Solvent: Mass fraction - 4; Liquid	Pressure, kPa; Liquid Temperature, K; Liquid	Liquid Crystal 1 - 2	titration method	5

Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Solubility of Forms I and II of Clopidogrel Hydrogen Sulfate in Formic Acid, N-Methylpyrrolidone, and N,N-Dimethylformamide

Jim, M.[Mensah], Kim, K. -J.[Kwang-Joo]

ABSTRACT