Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Phase Equilibria, Crystallization and Microstructural Studies of Flunixin Meglumine + Meglumine system

Wu, S.[Songgu], Jiang, X. B.[Xiao Bin], Dong, W.[Weibing], Gong, J.[Junbo]
J. Chem. Eng. Data 2012, 57, 1, 204-207
ABSTRACT
The phase diagram of Flunixin meglumine + meglumine system has been investigated with the method of differential scanning calorimetry (DSC). The results show that the Flunixin meglumine and meglumine hold the formation of a simple eutectic mixture. Linear velocity of solidification of both pure components and the eutectic mixture was determined at different undercooling rates. The fusion enthalpy and the linear velocity of crystallization indicate the nonideal properties of the eutectic mixture in the melt. The roughness parameter of the eutectic system was calculated from the enthalpy of fusion value. The anisotropic and isotropic crystallizations of Flunixin meglumine, meglumine and the eutectic mixture were studied.
Compounds
# Formula Name
1 C21H28F3N3O7 (2R,3R,4R,5S)-6-methylaminohexane-1,2,3,4,5-pentaol; 2-[2-methyl-3-(trifluoromethyl)anilino]pyridine-3-carboxylic acid
2 C7H17NO5 (2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentaol
Datasets
The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type Compound-# Property Variable Constraint Phase Method #Points
  • POMD
  • 1
  • Molar enthalpy of transition or fusion, kJ/mol ; Crystal
  • Crystal
  • Liquid
  • Air at 1 atmosphere
  • DSC
  • 1
  • POMD
  • 1
  • Normal melting temperature, K ; Crystal
  • Crystal
  • Liquid
  • Air at 1 atmosphere
  • DTA:UFactor:2
  • 1
  • POMD
  • 2
  • Molar enthalpy of transition or fusion, kJ/mol ; Crystal
  • Crystal
  • Liquid
  • Air at 1 atmosphere
  • DSC
  • 1
  • POMD
  • 2
  • Normal melting temperature, K ; Crystal
  • Crystal
  • Liquid
  • Air at 1 atmosphere
  • DTA
  • 1
  • POMD
  • 2
  • 1
  • Eutectic temperature, K ; Crystal - 2
  • Crystal - 2
  • Crystal - 1
  • Liquid
  • Air at 1 atmosphere
  • DTA
  • 1
  • POMD
  • 2
  • 1
  • Eutectic composition: mole fraction - 2 ; Crystal - 2
  • Crystal - 2
  • Crystal - 1
  • Liquid
  • Air at 1 atmosphere
  • Derived from phase diagram analysis
  • 1
  • POMD
  • 2
  • 1
  • Solid-liquid equilibrium temperature, K ; Liquid
  • Mole fraction - 2; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 1
  • DTA:UFactor:2
  • 7
  • POMD
  • 2
  • 1
  • Solid-liquid equilibrium temperature, K ; Liquid
  • Mole fraction - 2; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 2
  • DTA
  • 6