Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Solubility Measurement of Diclofenac Acid in the Supercritical CO2

Zeinolabedini Hezave, A.[Ali], Esmaeilzadeh, F.[Feridun]
J. Chem. Eng. Data 2012, 57, 6, 1659-1664
ABSTRACT
The equilibrium solubility of the diclofenac acid in supercritical carbon dioxide was determined with a static method. The measurements were performed at pressures ranging from (120 to 400) bar and temperatures from (308.15 to 338.15) K. The results show that diclofenac acid solubility was increased by increasing pressure. The experimental solubility data were well correlated with enhanced density-based models including the Chrastil model, Mendez-Santiago and Teja model, Kumar and Johnston model, and the Bartle and co-workers model with an average absolute relative deviation (AARD) of 8.7 %, 6.6 %, 7.2 %, and 9.7 %, respectively. In addition, the solubility data satisfied the self-consistency test, proposed by Mendez-Santiago and Teja.
Compounds
# Formula Name
1 C15H13N3O4S 4-hydroxy-2-methyl-N-2-pyridinyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
2 C14H11Cl2NO2 (2-((2,6-dichlorophenyl)amino)phenyl)acetic acid
3 CO2 carbon dioxide
Datasets
The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type Compound-# Property Variable Constraint Phase Method #Points
  • POMD
  • 3
  • 1
  • Amount ratio of solute to solvent ; Fluid (supercritical or subcritical phases)
  • Pressure, kPa; Fluid (supercritical or subcritical phases)
  • Temperature, K; Fluid (supercritical or subcritical phases)
  • Fluid (supercritical or subcritical phases)
  • Crystal - 1
  • gravimetric
  • 4
  • POMD
  • 3
  • 2
  • Amount ratio of solute to solvent ; Fluid (supercritical or subcritical phases)
  • Temperature, K; Fluid (supercritical or subcritical phases)
  • Pressure, kPa; Fluid (supercritical or subcritical phases)
  • Fluid (supercritical or subcritical phases)
  • Crystal - 2
  • gravimetric
  • 32