ABSTRACT

The solubility of pioglitazone hydrochloride (form I) in methanol, ethanol, 1-propanol, acetic acid, and N,N-dimethylacetamide has been measured between 278.15 and 323.15 K at atmospheric pressure. The solubility of pioglitazone hydrochloride (form I) increases with increasing temperature and the order is N,N-dimethylacetamide greater than methanol greater than acetic acid greater than ethanol greater than1-propanol. The experimental data were correlated well by the Apelblat equation.

Compounds

#	Formula	Name
1	C19H21ClN2O3S	5-(4-(2-(5-ethylpyridin-2-yl)ethoxy)benzyl)thiazolidine-2,4-dione hydrochloride
2	CH4O	methanol
3	C2H6O	ethanol
4	C3H8O	propan-1-ol
5	C2H4O2	acetic acid
6	C4H9NO	N,N-dimethylethanamide

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	1	Normal melting temperature, K ; Crystal			Crystal Liquid Air at 1 atmosphere	DTA	1
POMD	2 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Laser monitoring	10
POMD	3 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Laser monitoring	10
POMD	4 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Laser monitoring	10
POMD	5 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Laser monitoring	8
POMD	6 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Laser monitoring	10

Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Solubilities of Pioglitazone Hydrochloride in Different Solvents

Tao, M.[Mengying], Wang, J.-K.[Jing-Kang], Wang, Y.[Yongli]

ABSTRACT