Effect of KCl on the Micellization and Clouding Phenomenon of the Amphiphilic Phenothiazine Drug Promethazine Hydrochloride: Some Thermodynamic Properties
Alam, M. S.[Md. Sayem], Mandal, A.[Abhishek], Mandal, A. B.[Asit Baran]
In the present paper, we report the micellization at different fixed temperatures [(293.15, 303.15, 313.15, and 323.15) K] and the clouding behavior of the phenothiazine drug 10-[2-(dimethylamino)propyl]phenothiazine hydrochloride (promethazine hydrochloride, PMT) in the absence and presence of KCl. The critical micelle concentration (cmc) of PMT was measured by the conductivity method. The cmc values decrease with increasing the KCl concentration, whereas with increasing temperature, the cmc values increase. The thermodynamic parameters, namely, the standard Gibbs energy (deltamGdeg ), standard enthalpy (deltamHdeg ), and standard entropy (deltamSdeg ) of micellization of PMT were evaluated, and they indicate greater stability of the PMT solution in the presence of KCl. PMT shows phase separation also. The cloud point (CP) of PMT decreases with increasing pH because of deprotonation of the drug molecules. The CP values increase with increasing KCl as well as PMT concentration because of micellar growth. Furthermore, the thermodynamic parameters were evaluated at the CP.
Compounds
#
Formula
Name
1
C17H21ClN2S
promethazine hydrochloride
2
H2O
water
3
ClK
potassium chloride
Datasets
The table above is generated from the ThermoML associated json file (link above).
POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied;
the numbers refer to the table of compounds on the left.