ABSTRACT

The solubilities of paracetamol and ibuprofen were determined in two different ionic liquids at temperatures of 298.15 K, 308.15 K, 318.15 K, 328.15 K, and 338.15 K. The ionic liquids selected were 1-butyl-3-methylimidazolium hexafluorophosphate [BMIM][PF6] and 1-hexyl-3-methylimidazolium hexafluorophosphate [HMIM][PF6]. In addition, solubility data for paracetamol and ibuprofen in water are reported at the same temperatures extending the data commonly reported in pharmaceutical reference texts. For all solvents the concentration of drug in solution was determined by UV spectrophotometry.

Compounds

#	Formula	Name
1	C8H15F6N2P	1-butyl-3-methylimidazolium hexafluorophosphate
2	C10H19F6N2P	1-hexyl-3-methylimidazolium hexafluorophosphate
3	C13H18O2	ibuprofen
4	C8H9NO2	N-acetyl-p-aminophenol
5	H2O	water

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	3 1	Mass concentration, kg/m3 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 3	UV Spectrophotometry	5
POMD	4 1	Mass concentration, kg/m3 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 4	UV Spectrophotometry	5
POMD	3 2	Mass concentration, kg/m3 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 3	UV Spectrophotometry	5
POMD	4 2	Mass concentration, kg/m3 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 4	UV Spectrophotometry	5
POMD	5 3	Mass concentration, kg/m3 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 3	UV Spectrophotometry	5
POMD	4 5	Mass concentration, kg/m3 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 4	UV Spectrophotometry	5

Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Solubilities of Pharmaceutical Compounds in Ionic Liquids

Smith, K. B., Bridson, R. H., Leeke, G. A.

ABSTRACT