ABSTRACT

The solubility data of candesartan cilexetil of form I in ethanol, 1-propanol, 2-propanol, acetone 2-butanone, and acetonitrile at various temperatures were measured by gravimetrical method under atmospheric pressure, and the solubility data was fitted well with the Apelblat equation. The results show that the solubility of form I in the above solvents increased with an increase of temperature, and at the same temperature, the order of solubility is 2-butanone greater than acetone greater than 1-propanol greater than ethanol greater than 2-propanol greater than acetonitrile.

Compounds

#	Formula	Name
1	C33H34N6O6	1-(((cyclohexyloxy)carbonyl)oxy)ethyl 1-((2-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate
2	C2H6O	ethanol
3	C3H8O	propan-1-ol
4	C3H8O	propan-2-ol
5	C3H6O	acetone
6	C4H8O	butanone
7	C2H3N	acetonitrile

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	5 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Gravimetric method	10
POMD	6 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Gravimetric method	12
POMD	7 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Gravimetric method	12
POMD	3 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Gravimetric method	12
POMD	4 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Gravimetric method	12
POMD	2 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Gravimetric method	12

Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Solubility of Candesartan Cilexetil in Different Solvents at Various Temperatures

Cui, P.[Penglei], Yin, Q.[Qiuxiang], Gong, J.[Junbo]

ABSTRACT