ABSTRACT

The solubilities of forms I and II of clopidogrel hydrogen sulfate (CHS) in methanol + 2-propanol mixture were measured over the temperature range of (-5 to +55) deg C and the methanol mass fraction range of (1.0 to 0.1). Enthalpy and entropy of dissolution of forms I and II of CHS in methanol +2-propanol were determined by using the van t Hoff equation. Form II had a lower solubility and a higher enthalpy of dissolution compared to those of form I, which indicated that form II was the stable form and form I was the metastable form at the studied temperature range of (-5 to +55) deg C.

Compounds

#	Formula	Name
1	C16H18ClNO6S2	(S)-(+)-Clopidogrel hydrogen sulfate
2	CH4O	methanol
3	C3H8O	propan-2-ol

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	2 1	Mass ratio of solute to solvent ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Metastable crystal - 1	titration	7
POMD	2 1	Mass ratio of solute to solvent ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	OTHER::sMethod:titration	7
POMD	2 3 1	Mass ratio of solute to solvent - 1 ; Liquid	Solvent: Mass fraction - 2; Liquid Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	titration	35
POMD	2 3 1	Mass ratio of solute to solvent - 1 ; Liquid	Solvent: Mass fraction - 2; Liquid Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Metastable crystal - 1	titration	35

Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Solubility of Forms I and II of Clopidogrel Hydrogen Sulfate in Methanol and 2-Propanol Mixture

Choi, W.-S.[Won-Suk], Kim, K.-J.[Kwang-Joo]

ABSTRACT