ABSTRACT

The solubility of cefuroxime acid in four pure solvents and three binary solvents formed by water + acetone, ethanol + acetone, and 2-propanol + acetone at atmospheric pressure has been measured via a laser monitoring observation technique over the temperature range from (278.5 to 313.4) K. The solubility of cefuroxime acid increased with increasing temperature in water, 2-propanol, and ethanol but decreased in acetone. The heat flux measurements by a Differential Scanning Calorimeter (DSC) and solubility with temperature behavior were consistent. The solubility data of cefuroxime acid in pure solvents were correlated by the modified Apelblat equation, and the maximum average absolute error (AAE) was 0.07. The solubility data of cefuroxime acid in binary solvents at various temperatures were fitted by the Jouyban-Acree model, and the maximum AAE was 0.06. The solubility of cefuroxime acid in binary solvents was significantly higher than that in pure solvents and showed a maximum at a specific volume fraction of acetone.

Compounds

#	Formula	Name
1	C16H16N4O8S	cefuroxime acid
2	C2H6O	ethanol
3	C3H8O	propan-2-ol
4	C3H6O	acetone
5	H2O	water

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	5 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Laser Monitoring Observation Technique	8
POMD	4 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Laser Monitoring Observation Technique	8
POMD	2 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Laser Monitoring Observation Technique	8
POMD	3 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Laser Monitoring Observation Technique	8
POMD	4 5 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid Solvent: Mole fraction - 4; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Laser Monitoring Observation Technique	56
POMD	2 4 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid Solvent: Mole fraction - 4; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Laser Monitoring Observation Technique	48
POMD	3 4 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid Solvent: Mole fraction - 4; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Laser Monitoring Observation Technique	48

Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Measurement and Correlation of Solubility of Cefuroxime Acid in Pure and Binary Solvents at Various Temperatures

Zhao, Y.[Yingying], Jiang, X.[Xiaobin], Hou, B.[Baohong]

ABSTRACT